| SP | Kazmir, S.Kazmir, Scott >> | 25 | 2008 | L | 87 | 28 | 28 | 10 | 12 | 3.41 | .281 | 1.15 | 6.5 | 3.9 | 8.6 | 171.2 | 123 | 71 | 65 | 16 | 75 | 164 | 1 | 0 | 0 | 1 | 17 | 3 | 2 | 3.67 |
| SP | Shields, J.Shields, James >> | 28 | 2007 | R | 90 | 28 | 28 | 12 | 12 | 3.65 | .289 | 1.20 | 8.5 | 2.3 | 7.2 | 207.0 | 195 | 93 | 84 | 29 | 53 | 166 | 9 | 0 | 0 | 2 | 18 | 5 | 6 | 4.06 |
| SP | Kennedy, J.Kennedy, Joe >> | 30 | 2001 | L | 90 | 29 | 29 | 11 | 10 | 4.40 | .300 | 1.26 | 9.5 | 1.9 | 6.9 | 188.1 | 198 | 99 | 92 | 19 | 40 | 144 | 0 | 0 | 0 | 0 | 16 | 4 | 6 | 3.48 |
| SP | Garza, M.Garza, Matt # >> | 26 | 2009 | R | 81 | 29 | 28 | 9 | 14 | 5.46 | .327 | 1.42 | 9.0 | 3.8 | 7.8 | 173.0 | 173 | 108 | 105 | 28 | 73 | 149 | 2 | 0 | 0 | 1 | 12 | 6 | 2 | 4.75 |
| SP | Saunders, T.Saunders, Tony >> | 34 | 1997 | L | 82 | 28 | 28 | 10 | 9 | 4.85 | .341 | 1.49 | 8.9 | 4.6 | 7.5 | 161.1 | 159 | 94 | 87 | 25 | 82 | 135 | 0 | 0 | 0 | 0 | 13 | 9 | 2 | 5.04 |
| RP | Balfour, G.Balfour, Grant >> | 32 | 2008 | R | 99 | 75 | 0 | 4 | 6 | 2.97 | .282 | 1.07 | 5.5 | 4.2 | 9.8 | 94.0 | 57 | 37 | 31 | 7 | 44 | 102 | 0 | 10 | 4 | 0 | 0 | 10 | 2 | 3.52 |
| RP | Colome, J.Colome, Jesus >> | 32 | 2004 | R | 86 | 67 | 0 | 4 | 1 | 3.11 | .294 | 1.24 | 6.9 | 4.3 | 6.9 | 84.0 | 64 | 34 | 29 | 8 | 40 | 64 | 0 | 11 | 2 | 0 | 0 | 1 | 1 | 4.18 |
| RP | Howell, J.Howell, J.P. >> | 26 | 2009 | L | 82 | 50 | 0 | 3 | 4 | 3.00 | .293 | 1.20 | 7.0 | 3.8 | 9.7 | 54.0 | 42 | 19 | 18 | 4 | 23 | 58 | 0 | 7 | 1 | 0 | 0 | 2 | 1 | 3.20 |
| RP | McClung, S.McClung, Seth >> | 28 | 2003 | R | 87 | 48 | 0 | 5 | 1 | 3.73 | .302 | 1.25 | 7.2 | 4.1 | 7.6 | 89.1 | 71 | 39 | 37 | 8 | 41 | 75 | 0 | 8 | 2 | 0 | 0 | 4 | 2 | 4.00 |
| RP | Zambrano, V.Zambrano, Victor >> | 34 | 2001 | R | 69 | 31 | 0 | 1 | 1 | 2.34 | .316 | 1.38 | 8.2 | 4.5 | 6.6 | 34.2 | 31 | 13 | 9 | 5 | 17 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.94 |
| RP | Choate, R.Choate, Randy >> | 34 | 2009 | L | 84 | 28 | 0 | 1 | 1 | 4.80 | .318 | 1.40 | 7.8 | 4.8 | 9.6 | 30.0 | 26 | 16 | 16 | 2 | 16 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.33 |