| SP | Hamels, C.Hamels, Cole † >> | 25 | 2008 | L | 94 | 28 | 28 | 17 | 6 | 3.98 | .294 | 1.24 | 8.4 | 2.8 | 6.5 | 205.2 | 192 | 94 | 91 | 23 | 63 | 148 | 1 | 0 | 0 | 0 | 17 | 2 | 0 | 3.97 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 1992 | R | 85 | 27 | 27 | 9 | 7 | 4.67 | .338 | 1.52 | 9.8 | 3.9 | 6.1 | 133.0 | 145 | 73 | 69 | 18 | 57 | 90 | 0 | 0 | 0 | 0 | 4 | 2 | 4 | 4.74 |
| CL | Wagner, B.Wagner, Billy † >> | 37 | 2008 | L | 99 | 59 | 0 | 1 | 3 | 3.21 | .289 | 1.22 | 9.2 | 1.9 | 10.5 | 53.1 | 54 | 21 | 19 | 8 | 11 | 62 | 0 | 42 | 3 | 0 | 0 | 0 | 1 | 3.25 |
| RP | Tejeda, R.Tejeda, Robinson † >> | 26 | 2008 | R | 92 | 70 | 0 | 11 | 3 | 2.36 | .254 | 1.00 | 4.5 | 4.5 | 8.5 | 118.1 | 59 | 35 | 31 | 5 | 59 | 111 | 0 | 2 | 1 | 0 | 0 | 3 | 9 | 3.25 |
| RP | Madson, R.Madson, Ryan >> | 28 | 2004 | R | 76 | 29 | 0 | 0 | 3 | 3.41 | .375 | 1.74 | 9.6 | 6.4 | 8.4 | 31.2 | 33 | 14 | 12 | 5 | 22 | 29 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 5.55 |
| SP | Duckworth, B.Duckworth, Brandon >> | 32 | 2001 | R | 79 | 12 | 0 | 4 | 0 | 3.30 | .280 | 1.15 | 7.7 | 2.8 | 6.8 | 62.2 | 53 | 23 | 23 | 4 | 19 | 47 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.29 |
| SP | Padilla, V.Padilla, Vicente >> | 31 | 2002 | R | 81 | 6 | 0 | 0 | 2 | 4.76 | .333 | 1.50 | 9.0 | 4.9 | 7.4 | 11.1 | 11 | 6 | 6 | 3 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.55 |