| SP | Hamels, C.Hamels, Cole >> | 26 | 2008 | L | 94 | 28 | 28 | 13 | 7 | 3.13 | .283 | 1.18 | 7.9 | 2.7 | 5.7 | 210.0 | 185 | 78 | 73 | 16 | 62 | 132 | 5 | 0 | 0 | 3 | 18 | 2 | 0 | 3.65 |
| SP | Myers, B.Myers, Brett † >> | 29 | 2005 | R | 86 | 28 | 28 | 18 | 5 | 3.72 | .289 | 1.20 | 7.5 | 3.3 | 7.9 | 201.0 | 168 | 87 | 83 | 20 | 74 | 177 | 0 | 0 | 0 | 0 | 19 | 3 | 2 | 3.68 |
| SP | Schilling, C.Schilling, Curt >> | 37 | 1992 | R | 80 | 28 | 28 | 8 | 4 | 4.36 | .306 | 1.31 | 8.5 | 3.3 | 7.6 | 138.1 | 131 | 71 | 67 | 23 | 50 | 116 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.62 |
| CL | Wagner, B.Wagner, Billy † >> | 38 | 2008 | L | 94 | 62 | 0 | 2 | 4 | 3.19 | .294 | 1.23 | 8.5 | 2.7 | 10.2 | 53.2 | 50 | 19 | 19 | 5 | 16 | 60 | 0 | 39 | 3 | 0 | 0 | 1 | 1 | 2.92 |
| RP | Tejeda, R.Tejeda, Robinson >> | 27 | 2008 | R | 97 | 71 | 0 | 15 | 2 | 4.03 | .324 | 1.43 | 8.2 | 4.7 | 9.9 | 116.0 | 106 | 52 | 52 | 9 | 60 | 128 | 0 | 1 | 2 | 0 | 0 | 1 | 13 | 3.38 |
| RP | Lidge, B.Lidge, Brad # >> | 33 | 2008 | R | 76 | 49 | 0 | 4 | 5 | 4.24 | .317 | 1.35 | 7.6 | 4.6 | 10.8 | 51.0 | 43 | 27 | 24 | 3 | 26 | 61 | 0 | 1 | 1 | 0 | 0 | 2 | 4 | 3.02 |
| RP | Madson, R.Madson, Ryan >> | 29 | 2004 | R | 75 | 53 | 0 | 4 | 1 | 4.41 | .340 | 1.48 | 11.0 | 2.4 | 6.7 | 63.1 | 77 | 34 | 31 | 8 | 17 | 47 | 0 | 4 | 2 | 0 | 0 | 4 | 6 | 4.16 |
| SP | Padilla, V.Padilla, Vicente >> | 32 | 2002 | R | 77 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |