| SP | Martinez, P.Martinez, Pedro † >> | 36 | 2005 | R | 99 | 22 | 22 | 11 | 7 | 3.54 | .279 | 1.10 | 7.8 | 2.1 | 8.3 | 150.0 | 130 | 60 | 59 | 14 | 35 | 138 | 1 | 0 | 0 | 0 | 15 | 9 | 1 | 3.25 |
| SP | Perez, O.Perez, Oliver >> | 26 | 2007 | L | 73 | 21 | 21 | 9 | 5 | 4.07 | .322 | 1.40 | 7.9 | 4.7 | 7.2 | 119.1 | 105 | 59 | 54 | 16 | 62 | 95 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 4.79 |
| CL | Dotel, O.Dotel, Octavio † >> | 34 | 2002 | R | 93 | 44 | 0 | 1 | 4 | 2.11 | .312 | 1.29 | 7.3 | 4.5 | 10.7 | 42.2 | 34 | 11 | 10 | 4 | 21 | 50 | 0 | 26 | 1 | 0 | 0 | 3 | 0 | 3.57 |
| RP | Wheeler, D.Wheeler, Dan >> | 30 | 2005 | R | 94 | 51 | 0 | 3 | 2 | 2.12 | .323 | 1.42 | 9.3 | 3.5 | 5.3 | 59.1 | 61 | 14 | 14 | 4 | 23 | 35 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.92 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 35 | 2007 | R | 91 | 47 | 0 | 3 | 0 | 2.64 | .263 | 1.05 | 6.1 | 3.4 | 7.5 | 47.2 | 32 | 14 | 14 | 6 | 18 | 39 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 4.21 |
| RP | Padilla, J.Padilla, Juan >> | 30 | 2005 | R | 87 | 26 | 0 | 3 | 1 | 1.56 | .241 | 0.92 | 6.1 | 2.4 | 6.4 | 34.2 | 23 | 6 | 6 | 1 | 9 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.85 |
| RP | Orosco, J.Orosco, Jesse >> | 35 | 1983 | L | 75 | 65 | 0 | 2 | 1 | 2.55 | .318 | 1.38 | 6.6 | 5.9 | 6.4 | 49.1 | 36 | 14 | 14 | 0 | 32 | 35 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.59 |