| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 26 | 26 | 11 | 8 | 4.63 | .306 | 1.31 | 8.7 | 3.1 | 7.8 | 149.2 | 144 | 89 | 77 | 18 | 52 | 129 | 0 | 0 | 0 | 0 | 15 | 2 | 5 | 3.93 |
| SP | Snell, B.Snell, Blake † $ >> | 25 | 2018 | L | 81 | 27 | 27 | 16 | 5 | 3.59 | .289 | 1.22 | 7.6 | 3.4 | 8.1 | 165.2 | 139 | 66 | 66 | 18 | 63 | 149 | 0 | 0 | 0 | 0 | 16 | 0 | 4 | 3.76 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 86 | 26 | 26 | 13 | 7 | 3.80 | .263 | 1.05 | 7.7 | 1.8 | 4.1 | 177.2 | 151 | 77 | 75 | 18 | 36 | 81 | 7 | 0 | 0 | 0 | 17 | 3 | 2 | 4.07 |
| SP | Darvish, Y.Darvish, Yu # >> | 35 | 2022 | R | 64 | 24 | 24 | 9 | 8 | 4.34 | .292 | 1.21 | 8.3 | 2.6 | 7.1 | 164.0 | 152 | 82 | 79 | 16 | 47 | 130 | 2 | 0 | 0 | 0 | 15 | 4 | 5 | 3.62 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 80 | 0 | 5 | 4 | 4.04 | .292 | 1.23 | 8.6 | 2.5 | 8.6 | 100.1 | 95 | 47 | 45 | 13 | 28 | 95 | 0 | 12 | 3 | 0 | 0 | 1 | 2 | 3.66 |
| RP | Miller, A.Miller, Andrew † >> | 29 | 2014 | L | 88 | 64 | 0 | 5 | 1 | 2.43 | .236 | 0.91 | 5.4 | 2.9 | 8.8 | 77.2 | 46 | 23 | 21 | 7 | 25 | 75 | 0 | 13 | 1 | 0 | 0 | 1 | 2 | 3.25 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 8 | 0 | 0 | 0 | 0.00 | .130 | 0.45 | 2.8 | 1.4 | 6.9 | 13.1 | 4 | 0 | 0 | 0 | 2 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.92 |
| RP | Radatz, D.Radatz, Dick >> | 27 | 1964 | R | 38 | 7 | 0 | 2 | 0 | 3.38 | .314 | 1.38 | 8.4 | 3.9 | 7.9 | 16.0 | 15 | 6 | 6 | 0 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.56 |