| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 28 | 28 | 19 | 6 | 3.32 | .271 | 1.10 | 7.0 | 2.9 | 8.6 | 219.2 | 171 | 85 | 81 | 17 | 70 | 209 | 14 | 0 | 0 | 2 | 19 | 4 | 5 | 3.11 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 27 | 27 | 16 | 9 | 4.28 | .314 | 1.36 | 9.0 | 3.3 | 5.3 | 193.1 | 192 | 101 | 92 | 27 | 70 | 114 | 9 | 0 | 0 | 1 | 14 | 3 | 4 | 4.77 |
| SP | Ryan, N.Ryan, Nolan # $ >> | 44 | 1991 | R | 73 | 27 | 27 | 10 | 6 | 4.73 | .332 | 1.47 | 8.5 | 4.8 | 8.5 | 159.2 | 150 | 90 | 84 | 18 | 84 | 151 | 2 | 0 | 0 | 2 | 13 | 4 | 6 | 4.23 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 27 | 27 | 10 | 10 | 5.50 | .341 | 1.53 | 10.4 | 3.5 | 7.9 | 171.2 | 197 | 112 | 105 | 26 | 66 | 151 | 1 | 0 | 0 | 0 | 12 | 4 | 6 | 4.44 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 24 | 24 | 11 | 6 | 5.20 | .347 | 1.58 | 9.1 | 5.2 | 4.3 | 154.0 | 155 | 94 | 89 | 18 | 89 | 73 | 1 | 0 | 0 | 0 | 13 | 2 | 3 | 5.34 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 61 | 0 | 4 | 3 | 2.75 | .271 | 1.10 | 5.0 | 4.9 | 9.5 | 75.1 | 42 | 23 | 23 | 3 | 41 | 79 | 0 | 13 | 1 | 0 | 0 | 1 | 5 | 3.09 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 52 | 0 | 4 | 8 | 3.26 | .287 | 1.18 | 9.7 | 1.0 | 7.6 | 66.1 | 71 | 27 | 24 | 12 | 7 | 56 | 0 | 11 | 4 | 0 | 0 | 2 | 0 | 4.08 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 32 | 0 | 2 | 1 | 3.86 | .281 | 1.17 | 5.9 | 4.6 | 6.9 | 35.0 | 23 | 16 | 15 | 6 | 18 | 27 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 5.23 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 18 | 0 | 2 | 0 | 1.44 | .219 | 0.84 | 5.4 | 2.2 | 8.3 | 25.0 | 15 | 5 | 4 | 1 | 6 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.40 |