| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 19 | 19 | 4 | 12 | 5.07 | .309 | 1.32 | 8.7 | 3.1 | 7.9 | 126.0 | 122 | 72 | 71 | 19 | 44 | 111 | 2 | 0 | 0 | 1 | 10 | 3 | 5 | 4.32 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 18 | 18 | 8 | 9 | 5.08 | .343 | 1.54 | 11.5 | 2.4 | 5.2 | 117.0 | 149 | 69 | 66 | 13 | 31 | 68 | 2 | 0 | 0 | 0 | 5 | 3 | 3 | 4.15 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 18 | 18 | 4 | 8 | 5.15 | .325 | 1.43 | 9.5 | 3.3 | 6.2 | 117.0 | 124 | 69 | 67 | 16 | 43 | 81 | 1 | 0 | 0 | 1 | 9 | 2 | 1 | 4.55 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 18 | 18 | 3 | 10 | 7.28 | .367 | 1.71 | 11.6 | 3.9 | 6.0 | 97.2 | 125 | 82 | 79 | 15 | 42 | 65 | 0 | 0 | 0 | 0 | 5 | 3 | 8 | 5.06 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 43 | 0 | 0 | 2 | 3.15 | .249 | 0.99 | 5.0 | 4.0 | 7.2 | 54.1 | 30 | 20 | 19 | 6 | 24 | 43 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 4.19 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 46 | 0 | 1 | 6 | 3.08 | .251 | 0.99 | 6.9 | 2.1 | 10.0 | 52.2 | 40 | 18 | 18 | 5 | 12 | 58 | 0 | 16 | 3 | 0 | 0 | 1 | 1 | 2.77 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 41 | 0 | 5 | 0 | 4.05 | .333 | 1.48 | 7.8 | 5.7 | 9.0 | 46.2 | 40 | 23 | 21 | 9 | 29 | 46 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 5.50 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 31 | 0 | 1 | 0 | 4.29 | .327 | 1.40 | 9.0 | 3.9 | 7.2 | 35.2 | 35 | 17 | 17 | 4 | 15 | 28 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.34 |
| SP | Carpenter, C.Carpenter, Chris >> | 30 | 2005 | R | 19 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |