| SP | Kershaw, C.Kershaw, Clayton $ >> | 28 | 2016 | L | 99 | 28 | 28 | 11 | 11 | 3.28 | .277 | 1.13 | 8.4 | 1.8 | 7.8 | 203.0 | 189 | 80 | 74 | 25 | 40 | 176 | 1 | 0 | 0 | 0 | 20 | 4 | 2 | 3.52 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 27 | 27 | 10 | 9 | 4.44 | .319 | 1.40 | 8.5 | 4.2 | 5.6 | 164.1 | 154 | 83 | 81 | 19 | 76 | 102 | 0 | 0 | 0 | 0 | 16 | 1 | 2 | 4.67 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 9 | 11 | 4.08 | .302 | 1.28 | 8.3 | 3.2 | 4.4 | 145.2 | 134 | 70 | 66 | 17 | 52 | 71 | 0 | 0 | 0 | 0 | 10 | 3 | 5 | 4.68 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 26 | 26 | 6 | 18 | 6.67 | .343 | 1.54 | 10.7 | 3.2 | 5.0 | 162.0 | 192 | 126 | 120 | 33 | 58 | 90 | 4 | 0 | 0 | 1 | 5 | 4 | 2 | 5.69 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 63 | 0 | 4 | 7 | 3.74 | .273 | 1.10 | 6.0 | 3.9 | 9.9 | 67.1 | 45 | 29 | 28 | 9 | 29 | 74 | 0 | 25 | 4 | 0 | 0 | 2 | 1 | 3.93 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 57 | 0 | 3 | 2 | 2.85 | .292 | 1.22 | 7.2 | 3.8 | 7.4 | 66.1 | 53 | 21 | 21 | 6 | 28 | 54 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.86 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 76 | 0 | 2 | 3 | 4.12 | .309 | 1.32 | 7.6 | 4.4 | 8.9 | 91.2 | 77 | 42 | 42 | 11 | 44 | 90 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 4.11 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 59 | 0 | 2 | 3 | 4.38 | .301 | 1.28 | 8.8 | 2.8 | 8.1 | 72.0 | 70 | 36 | 35 | 13 | 22 | 65 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.50 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 54 | 0 | 2 | 1 | 3.94 | .332 | 1.41 | 7.7 | 5.2 | 5.9 | 61.2 | 52 | 27 | 27 | 6 | 35 | 40 | 0 | 1 | 1 | 0 | 0 | 5 | 2 | 4.93 |