| SP | Arrieta, J.Arrieta, Jake >> | 27 | 2015 | R | 84 | 33 | 33 | 11 | 18 | 4.60 | .309 | 1.32 | 8.8 | 3.1 | 8.0 | 215.0 | 210 | 118 | 110 | 42 | 73 | 191 | 6 | 0 | 0 | 2 | 16 | 6 | 4 | 4.87 |
| SP | Santana, J.Santana, Johan >> | 26 | 2004 | L | 77 | 32 | 32 | 8 | 17 | 5.44 | .339 | 1.49 | 9.6 | 3.8 | 8.6 | 198.2 | 212 | 124 | 120 | 37 | 84 | 189 | 4 | 0 | 0 | 0 | 13 | 9 | 3 | 4.93 |
| SP | Harvey, M.Harvey, Matt >> | 25 | 2013 | R | 55 | 32 | 32 | 15 | 10 | 3.67 | .294 | 1.21 | 8.2 | 2.7 | 8.0 | 225.1 | 205 | 95 | 92 | 24 | 68 | 199 | 6 | 0 | 0 | 2 | 20 | 8 | 8 | 3.63 |
| RP | Uehara, K.Uehara, Koji >> | 39 | 2013 | R | 91 | 83 | 0 | 5 | 8 | 4.50 | .293 | 1.20 | 8.7 | 2.1 | 10.0 | 98.0 | 95 | 50 | 49 | 17 | 23 | 109 | 0 | 8 | 7 | 0 | 0 | 4 | 2 | 3.86 |
| RP | Clippard, T.Clippard, Tyler >> | 27 | 2011 | R | 82 | 48 | 0 | 1 | 0 | 3.66 | .289 | 1.15 | 6.7 | 3.7 | 8.8 | 59.0 | 44 | 24 | 24 | 13 | 24 | 58 | 0 | 4 | 2 | 0 | 0 | 4 | 0 | 5.32 |
| RP | Percival, T.Percival, Troy >> | 28 | 1996 | R | 77 | 36 | 0 | 2 | 1 | 2.40 | .293 | 1.18 | 6.4 | 4.2 | 10.6 | 45.0 | 32 | 12 | 12 | 4 | 21 | 53 | 0 | 4 | 0 | 0 | 0 | 3 | 2 | 3.40 |
| RP | Feliz, N.Feliz, Neftali >> | 23 | 2010 | R | 70 | 32 | 0 | 2 | 1 | 1.54 | .241 | 0.95 | 4.6 | 4.0 | 7.7 | 41.0 | 21 | 7 | 7 | 4 | 18 | 35 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.88 |
| SP | Johnson, R.Johnson, Randy >> | 32 | 1995 | L | 37 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Ohtani, S.Ohtani, Shohei >> | 28 | 2022 | R | 50 | 3 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 13.5 | 2.2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |