| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 10 | 10 | 7 | 1 | 4.29 | .275 | 1.11 | 7.5 | 2.5 | 9.4 | 65.0 | 54 | 32 | 31 | 8 | 18 | 68 | 1 | 0 | 0 | 1 | 6 | 2 | 0 | 3.43 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 10 | 10 | 4 | 2 | 4.48 | .332 | 1.46 | 9.5 | 3.7 | 8.7 | 68.1 | 72 | 42 | 34 | 4 | 28 | 66 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 3.15 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 10 | 10 | 4 | 5 | 5.37 | .347 | 1.58 | 10.1 | 4.2 | 8.5 | 67.0 | 75 | 41 | 40 | 12 | 31 | 63 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.88 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 10 | 10 | 5 | 2 | 5.88 | .344 | 1.54 | 10.1 | 3.9 | 5.1 | 56.2 | 63 | 38 | 37 | 6 | 24 | 32 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.64 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 2 | 0 | 0 | 0 | 12.00 | .438 | 2.33 | 21.0 | 0.0 | 3.0 | 3.0 | 7 | 4 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.67 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 21 | 0 | 2 | 4 | 4.94 | .295 | 1.23 | 8.1 | 2.9 | 7.3 | 31.0 | 28 | 19 | 17 | 8 | 10 | 25 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 5.81 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 20 | 0 | 0 | 2 | 2.67 | .308 | 1.22 | 8.0 | 3.0 | 8.7 | 27.0 | 24 | 8 | 8 | 1 | 9 | 26 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 2.89 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 78 | 15 | 0 | 2 | 0 | 2.12 | .227 | 0.88 | 4.8 | 3.2 | 9.5 | 17.0 | 9 | 4 | 4 | 0 | 6 | 18 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 1.94 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 8 | 0 | 0 | 0 | 2.00 | .156 | 0.56 | 3.0 | 2.0 | 14.0 | 9.0 | 3 | 2 | 2 | 1 | 2 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.00 |