| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 23 | 23 | 7 | 6 | 3.20 | .272 | 1.11 | 8.0 | 2.1 | 8.9 | 140.2 | 124 | 51 | 50 | 16 | 32 | 138 | 0 | 0 | 0 | 0 | 17 | 2 | 0 | 3.24 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 91 | 22 | 22 | 7 | 9 | 5.62 | .309 | 1.32 | 8.9 | 3.0 | 11.1 | 121.2 | 119 | 76 | 76 | 25 | 41 | 149 | 1 | 0 | 0 | 1 | 11 | 3 | 4 | 4.31 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 81 | 21 | 21 | 11 | 8 | 3.60 | .287 | 1.19 | 7.6 | 3.2 | 7.2 | 142.1 | 120 | 63 | 57 | 17 | 50 | 114 | 2 | 0 | 0 | 0 | 14 | 2 | 3 | 4.05 |
| CL | Capps, C.Capps, Carter † >> | 24 | 2015 | R | 83 | 49 | 0 | 6 | 6 | 3.23 | .300 | 1.26 | 8.2 | 3.2 | 12.2 | 53.0 | 48 | 19 | 19 | 6 | 19 | 72 | 0 | 19 | 4 | 0 | 0 | 1 | 1 | 2.89 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 47 | 0 | 3 | 3 | 3.42 | .262 | 1.06 | 5.2 | 4.5 | 9.7 | 52.2 | 30 | 20 | 20 | 3 | 26 | 56 | 0 | 4 | 5 | 0 | 0 | 0 | 3 | 3.10 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 61 | 38 | 0 | 1 | 0 | 3.75 | .287 | 1.17 | 7.5 | 3.0 | 9.4 | 24.0 | 20 | 10 | 10 | 3 | 8 | 25 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.67 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 36 | 0 | 3 | 0 | 4.73 | .307 | 1.30 | 9.8 | 2.0 | 9.0 | 32.1 | 35 | 17 | 17 | 6 | 7 | 32 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.19 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 29 | 0 | 1 | 0 | 3.46 | .371 | 1.73 | 10.0 | 5.5 | 9.7 | 26.0 | 29 | 10 | 10 | 1 | 16 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.31 |