| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 22 | 22 | 7 | 9 | 4.31 | .307 | 1.30 | 7.5 | 4.2 | 10.0 | 140.0 | 117 | 67 | 67 | 14 | 65 | 156 | 1 | 0 | 0 | 1 | 13 | 4 | 3 | 3.55 |
| SP | Fernandez, J.Fernandez, Jose † >> | 21 | 2013 | R | 82 | 22 | 22 | 9 | 6 | 3.16 | .309 | 1.30 | 7.4 | 4.3 | 8.9 | 139.2 | 115 | 58 | 49 | 12 | 67 | 138 | 1 | 0 | 0 | 1 | 13 | 5 | 1 | 3.69 |
| SP | Perry, G.Perry, Gaylord # >> | 34 | 1972 | R | 67 | 21 | 21 | 6 | 11 | 6.07 | .347 | 1.58 | 10.4 | 3.9 | 5.8 | 132.0 | 152 | 92 | 89 | 29 | 57 | 85 | 3 | 0 | 0 | 1 | 5 | 1 | 1 | 5.89 |
| SP | Higuera, T.Higuera, Teddy # >> | 30 | 1988 | L | 64 | 21 | 21 | 5 | 15 | 5.88 | .319 | 1.37 | 9.2 | 3.1 | 6.5 | 124.0 | 127 | 82 | 81 | 27 | 43 | 90 | 3 | 0 | 0 | 1 | 8 | 4 | 0 | 5.52 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 21 | 21 | 7 | 9 | 6.17 | .365 | 1.68 | 10.4 | 4.8 | 9.9 | 119.2 | 138 | 93 | 82 | 21 | 63 | 131 | 0 | 0 | 0 | 0 | 9 | 5 | 5 | 4.81 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 60 | 0 | 1 | 3 | 4.19 | .284 | 1.18 | 9.0 | 1.7 | 9.7 | 81.2 | 81 | 38 | 38 | 9 | 15 | 87 | 0 | 5 | 2 | 0 | 0 | 1 | 3 | 2.89 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 49 | 0 | 4 | 1 | 3.41 | .266 | 1.04 | 7.4 | 2.1 | 10.7 | 60.2 | 49 | 23 | 23 | 14 | 14 | 71 | 0 | 6 | 3 | 0 | 0 | 3 | 1 | 4.52 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 67 | 41 | 0 | 3 | 6 | 4.88 | .314 | 1.32 | 7.0 | 4.9 | 7.2 | 55.1 | 43 | 32 | 30 | 9 | 30 | 44 | 0 | 3 | 1 | 0 | 0 | 3 | 6 | 5.33 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 49 | 33 | 0 | 1 | 0 | 2.57 | .292 | 1.24 | 6.9 | 4.3 | 10.3 | 42.0 | 32 | 12 | 12 | 4 | 20 | 48 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.38 |