| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 13 | 7 | 3.38 | .254 | 1.01 | 7.0 | 2.1 | 10.1 | 173.0 | 134 | 66 | 65 | 29 | 40 | 194 | 1 | 0 | 0 | 0 | 23 | 3 | 0 | 3.68 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 79 | 26 | 26 | 15 | 7 | 3.49 | .289 | 1.19 | 7.7 | 3.0 | 7.1 | 172.2 | 148 | 70 | 67 | 19 | 58 | 136 | 4 | 0 | 0 | 0 | 16 | 5 | 8 | 3.95 |
| CL | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 94 | 57 | 0 | 2 | 3 | 1.98 | .271 | 1.07 | 6.7 | 3.0 | 7.3 | 63.2 | 47 | 15 | 14 | 5 | 21 | 51 | 0 | 33 | 1 | 0 | 0 | 3 | 1 | 3.56 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 64 | 0 | 2 | 3 | 2.61 | .284 | 1.17 | 7.3 | 3.3 | 9.1 | 69.0 | 56 | 21 | 20 | 7 | 25 | 70 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 3.42 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 44 | 0 | 2 | 1 | 2.49 | .236 | 0.91 | 4.1 | 4.1 | 9.2 | 50.2 | 23 | 14 | 14 | 4 | 23 | 51 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Orosco, J.Orosco, Jesse >> | 27 | 1984 | L | 25 | 31 | 0 | 3 | 1 | 2.10 | .274 | 1.09 | 5.4 | 4.7 | 5.4 | 25.2 | 15 | 6 | 6 | 2 | 13 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.52 |
| RP | Franco, J.Franco, John >> | 28 | 1988 | L | 26 | 22 | 0 | 1 | 0 | 0.41 | .205 | 0.77 | 3.3 | 3.7 | 5.3 | 22.0 | 8 | 1 | 1 | 0 | 9 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.05 |