| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 27 | 27 | 12 | 6 | 2.97 | .234 | 0.90 | 6.4 | 1.6 | 11.1 | 176.0 | 126 | 59 | 58 | 16 | 32 | 217 | 1 | 0 | 0 | 1 | 20 | 3 | 0 | 2.31 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 25 | 25 | 4 | 8 | 3.97 | .295 | 1.21 | 7.7 | 3.2 | 5.8 | 136.0 | 117 | 63 | 60 | 20 | 48 | 87 | 0 | 0 | 0 | 0 | 8 | 6 | 2 | 4.82 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 24 | 24 | 11 | 8 | 3.94 | .293 | 1.20 | 7.4 | 3.4 | 5.6 | 139.1 | 114 | 64 | 61 | 20 | 53 | 87 | 1 | 0 | 0 | 0 | 15 | 6 | 4 | 4.89 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 55 | 0 | 2 | 8 | 3.13 | .261 | 1.01 | 6.6 | 2.6 | 11.1 | 60.1 | 44 | 21 | 21 | 8 | 17 | 74 | 0 | 34 | 4 | 0 | 0 | 3 | 0 | 3.27 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 55 | 0 | 2 | 1 | 3.20 | .269 | 1.10 | 7.6 | 2.3 | 11.1 | 59.0 | 50 | 23 | 21 | 7 | 15 | 73 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 59 | 0 | 6 | 0 | 1.84 | .218 | 0.84 | 5.7 | 1.9 | 8.8 | 58.2 | 37 | 12 | 12 | 6 | 12 | 57 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 39 | 0 | 4 | 1 | 2.66 | .233 | 0.89 | 4.1 | 4.1 | 9.0 | 40.2 | 18 | 13 | 12 | 5 | 18 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 26 | 0 | 4 | 1 | 3.27 | .298 | 1.14 | 6.5 | 3.7 | 9.0 | 22.0 | 16 | 8 | 8 | 3 | 9 | 22 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.41 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 66 | 9 | 0 | 1 | 0 | 2.92 | .327 | 1.46 | 8.3 | 5.3 | 6.0 | 12.1 | 11 | 5 | 4 | 1 | 7 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.50 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 76 | 12 | 0 | 1 | 1 | 2.76 | .269 | 1.04 | 6.8 | 2.8 | 11.3 | 16.1 | 12 | 5 | 5 | 1 | 5 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2.44 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 31 | 57 | 0 | 1 | 2 | 2.49 | .299 | 1.26 | 7.5 | 3.8 | 7.9 | 47.0 | 39 | 14 | 13 | 4 | 20 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.70 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 21 | 0 | 3 | 3 | 3.34 | .261 | 1.03 | 6.3 | 3.0 | 5.1 | 94.1 | 66 | 36 | 35 | 11 | 31 | 53 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.48 |