| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 98 | 35 | 35 | 12 | 10 | 3.46 | .279 | 1.13 | 8.5 | 1.6 | 9.6 | 237.0 | 225 | 97 | 91 | 31 | 43 | 252 | 6 | 0 | 0 | 2 | 22 | 7 | 9 | 3.21 |
| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 91 | 34 | 34 | 18 | 7 | 3.37 | .252 | 1.00 | 6.6 | 2.4 | 8.2 | 221.2 | 163 | 85 | 83 | 30 | 58 | 202 | 4 | 0 | 0 | 2 | 22 | 3 | 3 | 3.76 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 33 | 33 | 12 | 14 | 4.36 | .317 | 1.36 | 8.6 | 3.7 | 6.1 | 177.1 | 170 | 105 | 86 | 28 | 72 | 119 | 0 | 0 | 0 | 0 | 15 | 5 | 5 | 5.02 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 32 | 32 | 2 | 8 | 4.45 | .323 | 1.43 | 9.4 | 3.5 | 8.9 | 127.1 | 133 | 63 | 63 | 14 | 49 | 125 | 0 | 0 | 0 | 0 | 2 | 0 | 4 | 3.62 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 60 | 31 | 31 | 14 | 8 | 4.35 | .305 | 1.31 | 7.9 | 3.9 | 5.4 | 180.0 | 157 | 89 | 87 | 23 | 78 | 107 | 0 | 0 | 0 | 0 | 17 | 2 | 5 | 4.81 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 95 | 101 | 0 | 8 | 6 | 2.49 | .230 | 0.88 | 5.6 | 2.4 | 9.6 | 126.1 | 78 | 36 | 35 | 14 | 33 | 134 | 0 | 7 | 2 | 0 | 0 | 2 | 5 | 3.15 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 85 | 0 | 4 | 3 | 2.71 | .252 | 0.96 | 6.4 | 2.3 | 8.3 | 66.1 | 47 | 21 | 20 | 5 | 17 | 61 | 0 | 11 | 3 | 0 | 0 | 3 | 0 | 3.05 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 56 | 0 | 3 | 4 | 3.35 | .279 | 1.12 | 6.1 | 4.0 | 10.5 | 43.0 | 29 | 16 | 16 | 5 | 19 | 50 | 0 | 9 | 2 | 0 | 0 | 2 | 4 | 3.65 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 71 | 28 | 0 | 1 | 0 | 1.27 | .267 | 1.06 | 4.2 | 5.5 | 9.0 | 28.1 | 13 | 4 | 4 | 3 | 17 | 28 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 4.32 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 54 | 77 | 0 | 4 | 4 | 3.24 | .286 | 1.20 | 6.1 | 4.8 | 4.6 | 41.2 | 28 | 15 | 15 | 4 | 22 | 21 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.85 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 29 | 43 | 0 | 2 | 2 | 2.14 | .296 | 1.26 | 7.1 | 4.3 | 9.2 | 42.0 | 33 | 10 | 10 | 2 | 20 | 43 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.00 |