| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 26 | 26 | 14 | 7 | 3.46 | .301 | 1.27 | 7.6 | 3.8 | 8.5 | 177.0 | 150 | 71 | 68 | 24 | 75 | 168 | 3 | 0 | 0 | 2 | 17 | 4 | 2 | 4.20 |
| SP | McClanahan, S.McClanahan, Shane # >> | 25 | 2022 | L | 89 | 25 | 25 | 9 | 7 | 4.50 | .315 | 1.32 | 9.2 | 2.7 | 10.0 | 146.0 | 149 | 75 | 73 | 20 | 44 | 162 | 0 | 0 | 0 | 0 | 13 | 8 | 4 | 3.63 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 25 | 25 | 14 | 7 | 4.02 | .285 | 1.16 | 8.4 | 2.1 | 7.4 | 165.2 | 154 | 74 | 74 | 17 | 38 | 136 | 3 | 0 | 0 | 1 | 15 | 6 | 3 | 3.49 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 25 | 25 | 12 | 7 | 3.97 | .307 | 1.31 | 7.4 | 4.4 | 8.3 | 154.0 | 127 | 69 | 68 | 14 | 75 | 142 | 0 | 0 | 0 | 0 | 12 | 3 | 3 | 3.86 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 53 | 25 | 25 | 11 | 5 | 3.61 | .305 | 1.28 | 7.3 | 4.2 | 9.1 | 169.1 | 138 | 69 | 68 | 18 | 79 | 170 | 1 | 0 | 0 | 0 | 15 | 6 | 3 | 3.88 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 51 | 0 | 3 | 2 | 2.72 | .267 | 1.09 | 6.3 | 3.6 | 7.8 | 53.0 | 37 | 16 | 16 | 4 | 21 | 46 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.43 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 34 | 0 | 3 | 1 | 1.29 | .288 | 1.19 | 6.9 | 3.9 | 10.7 | 42.0 | 32 | 6 | 6 | 1 | 18 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.29 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 31 | 0 | 2 | 3 | 5.06 | .321 | 1.42 | 9.2 | 3.6 | 6.8 | 37.1 | 38 | 21 | 21 | 8 | 15 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.51 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 51 | 0 | 2 | 2 | 2.62 | .247 | 0.98 | 5.2 | 3.6 | 7.7 | 55.0 | 32 | 17 | 16 | 4 | 22 | 47 | 0 | 36 | 3 | 0 | 0 | 0 | 0 | 3.44 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 47 | 0 | 1 | 3 | 3.76 | .269 | 1.10 | 6.6 | 3.5 | 11.4 | 52.2 | 38 | 22 | 22 | 5 | 20 | 66 | 0 | 4 | 4 | 0 | 0 | 0 | 1 | 2.87 |