| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 4 | 4 | 2 | 1 | 3.08 | .269 | 1.10 | 8.0 | 2.1 | 9.3 | 26.1 | 23 | 9 | 9 | 2 | 6 | 27 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 2.62 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 3 | 3 | 0 | 2 | 4.50 | .333 | 1.44 | 9.0 | 4.0 | 7.0 | 18.0 | 18 | 14 | 9 | 3 | 8 | 14 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 5.11 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 3 | 3 | 0 | 1 | 9.82 | .382 | 1.80 | 14.5 | 2.0 | 7.0 | 18.1 | 29 | 20 | 20 | 9 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.78 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 3 | 3 | 2 | 1 | 3.20 | .289 | 1.17 | 6.6 | 4.3 | 5.2 | 19.2 | 14 | 8 | 7 | 2 | 9 | 11 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.79 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 3 | 3 | 0 | 1 | 6.62 | .384 | 1.87 | 14.3 | 3.2 | 5.8 | 17.2 | 27 | 16 | 13 | 2 | 6 | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.29 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 9 | 0 | 1 | 0 | 5.93 | .339 | 1.46 | 9.7 | 4.2 | 6.2 | 13.2 | 14 | 9 | 9 | 5 | 6 | 9 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 8.23 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 92 | 11 | 0 | 0 | 2 | 14.04 | .490 | 2.88 | 15.8 | 11.3 | 16.9 | 8.1 | 14 | 13 | 13 | 3 | 10 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.88 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 78 | 6 | 0 | 2 | 0 | 2.45 | .290 | 1.09 | 6.4 | 3.9 | 10.3 | 7.1 | 5 | 2 | 2 | 1 | 3 | 8 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.29 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 5 | 0 | 0 | 1 | 1.50 | .280 | 1.17 | 9.0 | 1.5 | 6.0 | 6.0 | 6 | 1 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.17 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 6 | 0 | 0 | 0 | 2.25 | .250 | 1.00 | 5.6 | 3.4 | 10.1 | 8.0 | 5 | 2 | 2 | 2 | 3 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.13 |