| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 31 | 31 | 14 | 11 | 3.28 | .297 | 1.23 | 8.5 | 2.6 | 9.4 | 203.0 | 192 | 82 | 74 | 16 | 58 | 211 | 1 | 0 | 0 | 0 | 20 | 7 | 0 | 2.91 |
| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 30 | 30 | 10 | 15 | 4.33 | .301 | 1.27 | 8.7 | 2.7 | 4.2 | 214.1 | 208 | 119 | 103 | 24 | 64 | 101 | 5 | 0 | 0 | 1 | 17 | 5 | 7 | 4.48 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 30 | 30 | 11 | 12 | 5.16 | .338 | 1.51 | 9.9 | 3.7 | 6.7 | 204.0 | 225 | 121 | 117 | 27 | 83 | 151 | 1 | 0 | 0 | 0 | 11 | 5 | 4 | 4.53 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 29 | 29 | 11 | 12 | 4.51 | .335 | 1.49 | 9.9 | 3.6 | 5.1 | 195.2 | 215 | 105 | 98 | 20 | 77 | 111 | 4 | 0 | 0 | 0 | 17 | 4 | 2 | 4.44 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 28 | 28 | 9 | 13 | 6.19 | .370 | 1.74 | 11.4 | 4.2 | 5.5 | 170.0 | 215 | 121 | 117 | 23 | 80 | 104 | 1 | 0 | 0 | 1 | 9 | 4 | 9 | 5.02 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 82 | 0 | 3 | 3 | 4.28 | .295 | 1.22 | 7.9 | 3.2 | 9.0 | 113.2 | 99 | 54 | 54 | 11 | 40 | 113 | 0 | 12 | 2 | 0 | 0 | 4 | 1 | 3.43 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 69 | 0 | 3 | 6 | 4.03 | .313 | 1.32 | 9.4 | 2.5 | 7.3 | 76.0 | 79 | 34 | 34 | 7 | 21 | 62 | 0 | 12 | 3 | 0 | 0 | 4 | 0 | 3.55 |
| RP | Urbina, U.Urbina, Ugueth # >> | 24 | 1998 | R | 59 | 41 | 0 | 1 | 1 | 4.30 | .327 | 1.39 | 7.8 | 4.7 | 6.8 | 46.0 | 40 | 23 | 22 | 7 | 24 | 35 | 0 | 3 | 0 | 0 | 0 | 3 | 1 | 5.22 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 19 | 0 | 4 | 2 | 6.08 | .333 | 1.50 | 10.4 | 3.5 | 4.5 | 26.2 | 30 | 18 | 18 | 4 | 10 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.15 |