| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 16 | 16 | 1 | 10 | 5.56 | .332 | 1.42 | 8.7 | 4.2 | 5.1 | 90.2 | 87 | 61 | 56 | 10 | 42 | 51 | 1 | 0 | 0 | 0 | 6 | 6 | 2 | 4.91 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 2 | 7 | 6.23 | .338 | 1.50 | 9.3 | 4.3 | 7.2 | 69.1 | 71 | 48 | 48 | 14 | 33 | 55 | 1 | 0 | 0 | 0 | 5 | 2 | 2 | 5.57 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 15 | 15 | 4 | 7 | 5.02 | .323 | 1.43 | 9.8 | 3.1 | 4.5 | 95.0 | 103 | 58 | 53 | 19 | 33 | 48 | 3 | 0 | 0 | 0 | 7 | 0 | 1 | 5.63 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 15 | 15 | 0 | 8 | 7.48 | .399 | 1.95 | 12.8 | 4.9 | 6.5 | 55.1 | 78 | 47 | 46 | 10 | 30 | 40 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 5.65 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 52 | 0 | 2 | 0 | 3.19 | .267 | 1.06 | 7.1 | 2.6 | 8.5 | 67.2 | 53 | 24 | 24 | 5 | 19 | 63 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.03 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 44 | 0 | 5 | 5 | 5.96 | .384 | 1.87 | 12.7 | 4.2 | 8.1 | 51.1 | 72 | 39 | 34 | 12 | 24 | 46 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 5.67 |
| CL | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 42 | 0 | 1 | 3 | 4.67 | .333 | 1.43 | 8.8 | 4.0 | 9.0 | 54.0 | 53 | 29 | 28 | 5 | 24 | 54 | 0 | 3 | 3 | 0 | 0 | 4 | 2 | 3.76 |