| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 15 | 15 | 5 | 5 | 5.96 | .308 | 1.31 | 9.1 | 2.7 | 8.0 | 83.0 | 84 | 57 | 55 | 18 | 25 | 74 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 5.01 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 15 | 15 | 6 | 4 | 4.45 | .326 | 1.45 | 9.1 | 3.9 | 4.7 | 87.0 | 88 | 45 | 43 | 8 | 38 | 45 | 2 | 0 | 0 | 1 | 7 | 0 | 2 | 4.47 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 16 | 13 | 4 | 4 | 5.37 | .335 | 1.49 | 9.8 | 3.8 | 5.0 | 60.1 | 65 | 41 | 36 | 8 | 25 | 33 | 0 | 1 | 0 | 0 | 5 | 1 | 2 | 4.93 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 14 | 14 | 7 | 4 | 3.22 | .282 | 1.15 | 8.0 | 2.4 | 10.2 | 89.1 | 79 | 38 | 32 | 12 | 24 | 101 | 1 | 0 | 0 | 1 | 10 | 2 | 1 | 3.36 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 14 | 13 | 7 | 4 | 3.79 | .299 | 1.24 | 8.1 | 3.2 | 6.6 | 80.2 | 72 | 37 | 34 | 10 | 28 | 59 | 2 | 0 | 0 | 2 | 7 | 3 | 3 | 4.31 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 38 | 0 | 0 | 2 | 4.60 | .345 | 1.58 | 9.0 | 5.2 | 7.5 | 43.0 | 43 | 22 | 22 | 6 | 25 | 36 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 33 | 0 | 4 | 1 | 6.16 | .313 | 1.34 | 6.9 | 5.2 | 7.8 | 38.0 | 29 | 27 | 26 | 5 | 22 | 33 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.79 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 26 | 0 | 2 | 1 | 3.97 | .325 | 1.41 | 7.7 | 5.0 | 6.9 | 34.0 | 29 | 17 | 15 | 5 | 19 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.15 |
| RP | Bautista, F.Bautista, Felix >> | 28 | 2023 | R | 75 | 24 | 0 | 2 | 1 | 3.77 | .328 | 1.43 | 7.1 | 6.1 | 7.1 | 28.2 | 22 | 13 | 12 | 5 | 19 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 5.89 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 9 | 2 | 1 | 4 | 5.63 | .308 | 1.29 | 9.4 | 2.3 | 6.0 | 24.0 | 25 | 15 | 15 | 2 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.63 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 26 | 0 | 0 | 1 | 2.28 | .265 | 1.08 | 8.7 | 1.3 | 7.3 | 27.2 | 26 | 8 | 7 | 3 | 4 | 22 | 0 | 14 | 0 | 0 | 0 | 0 | 0 | 3.26 |