| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 3 | 5 | 3.77 | .292 | 1.21 | 8.8 | 2.1 | 9.4 | 100.1 | 98 | 44 | 42 | 6 | 23 | 104 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 2.48 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 15 | 15 | 7 | 7 | 4.49 | .289 | 1.20 | 8.2 | 2.7 | 4.7 | 112.1 | 102 | 56 | 56 | 16 | 33 | 58 | 5 | 0 | 0 | 0 | 9 | 2 | 1 | 4.76 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 15 | 15 | 4 | 5 | 4.44 | .344 | 1.54 | 10.4 | 3.5 | 7.8 | 97.1 | 112 | 52 | 48 | 13 | 38 | 84 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.28 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 15 | 15 | 6 | 4 | 4.35 | .296 | 1.26 | 9.3 | 2.1 | 4.7 | 109.2 | 113 | 54 | 53 | 10 | 25 | 57 | 1 | 0 | 0 | 0 | 6 | 0 | 0 | 3.83 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 43 | 0 | 5 | 1 | 1.49 | .255 | 1.01 | 6.0 | 3.2 | 8.4 | 60.1 | 40 | 15 | 10 | 2 | 21 | 56 | 0 | 5 | 0 | 0 | 0 | 1 | 2 | 2.67 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 28 | 0 | 3 | 2 | 2.38 | .244 | 0.94 | 5.6 | 2.9 | 9.8 | 34.0 | 21 | 11 | 9 | 4 | 11 | 37 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 17 | 0 | 1 | 2 | 2.25 | .250 | 1.00 | 7.2 | 1.8 | 8.1 | 20.0 | 16 | 5 | 5 | 3 | 4 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.75 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 8 | 0 | 2 | 2 | 9.64 | .333 | 1.50 | 11.0 | 3.0 | 8.0 | 9.1 | 11 | 10 | 10 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.11 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 7 | 0 | 0 | 0 | 0.00 | .184 | 0.68 | 0.0 | 6.3 | 6.3 | 10.1 | 0 | 0 | 0 | 0 | 7 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.70 |