| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 31 | 31 | 13 | 9 | 4.09 | .303 | 1.28 | 8.4 | 3.2 | 6.6 | 178.1 | 166 | 81 | 81 | 12 | 63 | 131 | 0 | 0 | 0 | 0 | 18 | 4 | 5 | 3.53 |
| SP | Leonard, D.Leonard, Dutch # >> | 22 | 1914 | L | 91 | 30 | 30 | 11 | 12 | 3.30 | .283 | 1.18 | 7.8 | 2.8 | 4.8 | 199.1 | 172 | 78 | 73 | 18 | 63 | 107 | 5 | 0 | 0 | 2 | 22 | 1 | 5 | 4.07 |
| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 88 | 30 | 30 | 17 | 4 | 3.19 | .251 | 0.99 | 6.6 | 2.4 | 5.6 | 214.1 | 157 | 77 | 76 | 15 | 56 | 134 | 6 | 0 | 0 | 5 | 20 | 3 | 1 | 3.49 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 30 | 30 | 15 | 6 | 3.39 | .299 | 1.27 | 6.7 | 4.8 | 7.2 | 193.2 | 143 | 78 | 73 | 18 | 103 | 155 | 2 | 0 | 0 | 0 | 16 | 2 | 1 | 4.24 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 28 | 28 | 10 | 8 | 4.15 | .273 | 1.12 | 8.2 | 1.9 | 6.9 | 173.1 | 158 | 84 | 80 | 18 | 36 | 132 | 3 | 0 | 0 | 0 | 17 | 1 | 1 | 3.47 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 50 | 0 | 3 | 4 | 3.06 | .293 | 1.21 | 7.5 | 3.4 | 8.2 | 53.0 | 44 | 21 | 18 | 8 | 20 | 48 | 0 | 7 | 3 | 0 | 0 | 2 | 1 | 4.40 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 41 | 0 | 1 | 2 | 1.60 | .266 | 1.04 | 6.0 | 3.4 | 9.0 | 45.0 | 30 | 8 | 8 | 3 | 17 | 45 | 0 | 4 | 2 | 0 | 0 | 2 | 3 | 3.13 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 20 | 0 | 2 | 4 | 3.62 | .274 | 1.13 | 7.0 | 3.3 | 8.0 | 27.1 | 21 | 11 | 11 | 4 | 10 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.26 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 25 | 0 | 4 | 3 | 3.69 | .291 | 1.23 | 7.4 | 3.7 | 4.6 | 78.0 | 64 | 34 | 32 | 4 | 32 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.87 |