| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 18 | 18 | 13 | 1 | 2.04 | .251 | 0.99 | 6.7 | 2.3 | 10.8 | 128.0 | 95 | 29 | 29 | 9 | 32 | 154 | 0 | 0 | 0 | 0 | 16 | 2 | 0 | 2.30 |
| SP | Buehler, W.Buehler, Walker # >> | 23 | 2018 | R | 86 | 18 | 18 | 8 | 3 | 3.61 | .273 | 1.08 | 6.6 | 3.2 | 8.5 | 117.1 | 86 | 47 | 47 | 17 | 41 | 110 | 0 | 0 | 0 | 0 | 13 | 5 | 1 | 4.19 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 18 | 18 | 7 | 7 | 5.28 | .330 | 1.46 | 9.0 | 4.2 | 4.8 | 119.1 | 119 | 73 | 70 | 20 | 55 | 63 | 2 | 0 | 0 | 0 | 7 | 2 | 2 | 5.56 |
| SP | Alcantara, S.Alcantara, Sandy >> | 26 | 2022 | R | 70 | 17 | 17 | 5 | 6 | 5.95 | .352 | 1.61 | 10.5 | 4.0 | 5.6 | 101.1 | 118 | 67 | 67 | 17 | 45 | 63 | 1 | 0 | 0 | 0 | 5 | 2 | 3 | 5.34 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 17 | 17 | 4 | 3 | 5.27 | .352 | 1.61 | 10.0 | 4.5 | 8.3 | 80.1 | 89 | 47 | 47 | 9 | 40 | 74 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 4.19 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 49 | 0 | 6 | 2 | 2.79 | .259 | 1.05 | 3.9 | 5.6 | 7.9 | 67.2 | 29 | 21 | 21 | 4 | 42 | 59 | 0 | 11 | 5 | 0 | 0 | 0 | 9 | 3.90 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 48 | 0 | 3 | 3 | 3.66 | .319 | 1.37 | 8.2 | 4.1 | 10.5 | 59.0 | 54 | 24 | 24 | 12 | 27 | 69 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 4.78 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 32 | 0 | 1 | 4 | 4.63 | .286 | 1.20 | 7.5 | 3.3 | 8.2 | 35.0 | 29 | 19 | 18 | 8 | 13 | 32 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 5.26 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 57 | 9 | 0 | 2 | 0 | 11.25 | .442 | 2.38 | 13.5 | 7.9 | 6.8 | 8.0 | 12 | 10 | 10 | 3 | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |