| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 96 | 18 | 18 | 8 | 6 | 4.40 | .300 | 1.23 | 8.1 | 3.1 | 9.2 | 120.2 | 108 | 61 | 59 | 18 | 41 | 123 | 1 | 0 | 0 | 0 | 10 | 6 | 3 | 4.08 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 18 | 18 | 9 | 7 | 3.66 | .288 | 1.19 | 8.7 | 2.1 | 5.5 | 135.1 | 130 | 64 | 55 | 21 | 31 | 83 | 8 | 0 | 0 | 1 | 10 | 3 | 1 | 4.55 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 17 | 17 | 1 | 8 | 7.56 | .373 | 1.77 | 10.8 | 5.3 | 8.7 | 66.2 | 79 | 57 | 56 | 16 | 39 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 6.03 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 49 | 0 | 3 | 2 | 4.08 | .275 | 1.11 | 7.5 | 2.5 | 8.9 | 64.0 | 53 | 29 | 29 | 10 | 18 | 63 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 4.00 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 40 | 0 | 0 | 5 | 3.56 | .268 | 1.08 | 7.4 | 2.5 | 8.3 | 55.2 | 45 | 23 | 22 | 9 | 15 | 51 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 4.15 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 35 | 0 | 2 | 1 | 4.99 | .292 | 1.24 | 8.5 | 2.8 | 12.5 | 39.2 | 37 | 22 | 22 | 8 | 12 | 54 | 0 | 4 | 3 | 0 | 0 | 0 | 4 | 3.82 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 30 | 0 | 0 | 1 | 3.31 | .279 | 1.16 | 7.6 | 3.1 | 7.9 | 32.2 | 27 | 12 | 12 | 7 | 11 | 28 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 5.13 |
| SP | Wheeler, Z.Wheeler, Zack >> | 31 | 2021 | R | 58 | 5 | 0 | 1 | 0 | 3.86 | .300 | 1.29 | 6.8 | 6.8 | 15.8 | 4.2 | 3 | 2 | 2 | 1 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |