| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 35 | 35 | 14 | 10 | 3.21 | .265 | 1.04 | 7.1 | 2.3 | 10.3 | 229.2 | 181 | 87 | 82 | 26 | 58 | 262 | 0 | 0 | 0 | 0 | 23 | 9 | 5 | 3.07 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 34 | 34 | 13 | 5 | 3.84 | .320 | 1.38 | 7.8 | 4.6 | 10.0 | 178.0 | 155 | 80 | 76 | 18 | 90 | 197 | 0 | 0 | 0 | 0 | 7 | 6 | 5 | 3.72 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 83 | 33 | 33 | 16 | 5 | 3.74 | .277 | 1.11 | 7.6 | 2.4 | 7.3 | 204.1 | 172 | 86 | 85 | 31 | 55 | 165 | 0 | 0 | 0 | 0 | 19 | 8 | 3 | 4.28 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 33 | 33 | 16 | 13 | 4.37 | .325 | 1.39 | 9.5 | 3.1 | 10.5 | 187.1 | 197 | 96 | 91 | 26 | 64 | 218 | 0 | 0 | 0 | 0 | 12 | 10 | 3 | 3.66 |
| SP | Castillo, L.Castillo, Luis # >> | 32 | 2025 | R | 67 | 32 | 31 | 15 | 6 | 4.94 | .333 | 1.48 | 10.6 | 2.8 | 7.5 | 178.2 | 209 | 101 | 98 | 29 | 56 | 148 | 0 | 0 | 0 | 0 | 12 | 3 | 3 | 4.45 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 89 | 93 | 0 | 9 | 3 | 2.82 | .272 | 1.10 | 5.5 | 4.4 | 9.5 | 115.0 | 70 | 37 | 36 | 13 | 56 | 122 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 3.89 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 83 | 83 | 0 | 4 | 3 | 3.77 | .308 | 1.33 | 8.5 | 3.4 | 10.1 | 98.0 | 93 | 44 | 41 | 16 | 37 | 110 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.04 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 74 | 0 | 2 | 2 | 3.43 | .288 | 1.18 | 6.4 | 4.3 | 9.8 | 76.0 | 54 | 30 | 29 | 9 | 36 | 83 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.86 |
| SU | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 93 | 71 | 0 | 3 | 4 | 4.77 | .333 | 1.46 | 9.5 | 3.7 | 7.9 | 77.1 | 81 | 42 | 41 | 11 | 32 | 68 | 0 | 7 | 11 | 0 | 0 | 3 | 0 | 4.45 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 64 | 0 | 7 | 9 | 3.21 | .276 | 1.11 | 6.3 | 3.7 | 10.5 | 70.0 | 49 | 25 | 25 | 10 | 29 | 82 | 0 | 30 | 4 | 0 | 0 | 2 | 0 | 3.84 |