| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 26 | 26 | 14 | 7 | 3.49 | .290 | 1.20 | 8.2 | 2.6 | 11.4 | 167.2 | 152 | 68 | 65 | 23 | 49 | 212 | 0 | 0 | 0 | 0 | 16 | 4 | 3 | 3.20 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 79 | 24 | 24 | 9 | 4 | 4.62 | .316 | 1.35 | 9.8 | 2.4 | 7.8 | 132.1 | 144 | 71 | 68 | 19 | 35 | 114 | 0 | 0 | 0 | 0 | 10 | 4 | 5 | 4.03 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 24 | 24 | 8 | 6 | 6.56 | .371 | 1.74 | 11.7 | 3.9 | 9.4 | 118.0 | 154 | 88 | 86 | 29 | 51 | 123 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.51 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 63 | 0 | 7 | 2 | 2.85 | .282 | 1.16 | 7.4 | 3.1 | 9.1 | 91.2 | 75 | 29 | 29 | 9 | 31 | 92 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 3.35 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 66 | 0 | 8 | 3 | 5.04 | .324 | 1.40 | 9.2 | 3.4 | 11.2 | 75.0 | 77 | 44 | 42 | 17 | 28 | 93 | 0 | 0 | 6 | 0 | 0 | 3 | 0 | 4.71 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 77 | 56 | 0 | 5 | 0 | 3.82 | .268 | 1.07 | 6.6 | 3.0 | 10.6 | 68.1 | 50 | 30 | 29 | 8 | 23 | 80 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.28 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 70 | 56 | 0 | 4 | 0 | 2.97 | .326 | 1.42 | 8.4 | 4.5 | 8.0 | 60.2 | 56 | 20 | 20 | 5 | 30 | 53 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 3.92 |
| SU | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 91 | 58 | 0 | 1 | 1 | 2.62 | .312 | 1.36 | 6.8 | 5.5 | 11.8 | 65.1 | 49 | 20 | 19 | 3 | 40 | 85 | 0 | 2 | 2 | 0 | 0 | 0 | 6 | 2.83 |
| SP | Gore, M.Gore, MacKenzie >> | 26 | 2025 | L | 35 | 16 | 1 | 0 | 5 | 4.67 | .325 | 1.44 | 9.3 | 3.7 | 10.7 | 27.0 | 28 | 17 | 14 | 7 | 11 | 32 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 5.22 |