| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 8 | 8 | 6 | 2 | 3.02 | .236 | 0.91 | 6.1 | 2.2 | 8.8 | 50.2 | 34 | 19 | 17 | 7 | 12 | 49 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 3.64 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 8 | 8 | 4 | 2 | 4.97 | .342 | 1.54 | 9.4 | 4.6 | 10.5 | 41.2 | 43 | 23 | 23 | 5 | 21 | 48 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | 3.85 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 83 | 8 | 8 | 3 | 2 | 2.59 | .227 | 0.84 | 5.9 | 1.8 | 7.5 | 55.2 | 36 | 16 | 16 | 7 | 11 | 46 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 3.69 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 7 | 7 | 4 | 2 | 4.64 | .312 | 1.27 | 9.6 | 1.9 | 9.9 | 42.2 | 45 | 23 | 22 | 6 | 9 | 46 | 0 | 0 | 0 | 0 | 3 | 4 | 2 | 3.60 |
| SP | Castillo, L.Castillo, Luis # >> | 32 | 2025 | R | 67 | 7 | 7 | 3 | 0 | 6.00 | .337 | 1.48 | 10.5 | 2.8 | 6.6 | 42.0 | 49 | 28 | 28 | 5 | 13 | 31 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 4.14 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 89 | 23 | 0 | 2 | 1 | 4.15 | .297 | 1.23 | 5.9 | 5.2 | 8.0 | 26.0 | 17 | 12 | 12 | 3 | 15 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.58 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 83 | 16 | 0 | 1 | 1 | 2.65 | .378 | 1.76 | 11.6 | 4.2 | 15.4 | 17.0 | 22 | 6 | 5 | 2 | 8 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.71 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 16 | 0 | 0 | 0 | 4.32 | .265 | 1.08 | 6.8 | 3.4 | 7.9 | 16.2 | 12 | 8 | 8 | 3 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.81 |
| SU | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 93 | 16 | 0 | 1 | 1 | 3.94 | .284 | 1.13 | 6.8 | 3.4 | 6.2 | 16.0 | 12 | 7 | 7 | 1 | 6 | 11 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.75 |