| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 34 | 34 | 12 | 9 | 4.25 | .293 | 1.23 | 7.6 | 3.5 | 10.7 | 226.1 | 191 | 108 | 107 | 32 | 87 | 269 | 3 | 0 | 0 | 0 | 19 | 4 | 2 | 3.67 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 79 | 32 | 32 | 12 | 8 | 4.56 | .312 | 1.32 | 9.3 | 2.7 | 5.7 | 183.2 | 189 | 98 | 93 | 19 | 54 | 116 | 1 | 0 | 0 | 0 | 18 | 7 | 3 | 4.08 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 30 | 30 | 7 | 15 | 5.99 | .336 | 1.50 | 9.5 | 4.1 | 6.3 | 163.2 | 172 | 118 | 109 | 34 | 74 | 115 | 2 | 0 | 0 | 0 | 11 | 3 | 4 | 5.72 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 88 | 0 | 8 | 5 | 2.97 | .252 | 0.99 | 5.2 | 3.7 | 12.4 | 100.0 | 58 | 39 | 33 | 7 | 41 | 138 | 0 | 32 | 7 | 0 | 0 | 2 | 5 | 2.44 |
| RP | Rincon, J.Rincon, Juan † >> | 25 | 2004 | R | 59 | 80 | 0 | 8 | 3 | 2.28 | .281 | 1.13 | 6.2 | 4.0 | 11.2 | 94.2 | 65 | 29 | 24 | 12 | 42 | 117 | 0 | 2 | 5 | 0 | 0 | 4 | 6 | 3.64 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 54 | 96 | 0 | 10 | 1 | 2.36 | .268 | 1.08 | 6.7 | 3.1 | 8.3 | 106.2 | 79 | 28 | 28 | 9 | 36 | 98 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.33 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 9 | 0 | 1 | 1 | 2.92 | .275 | 1.14 | 5.3 | 5.3 | 7.5 | 12.1 | 7 | 4 | 4 | 1 | 7 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.17 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 58 | 50 | 0 | 8 | 5 | 5.81 | .351 | 1.61 | 10.5 | 4.1 | 6.8 | 83.2 | 97 | 57 | 54 | 11 | 38 | 63 | 0 | 11 | 5 | 0 | 0 | 1 | 1 | 4.61 |