| SP | Hunter, C.Hunter, Catfish † >> | 26 | 1972 | R | 92 | 22 | 22 | 11 | 7 | 3.31 | .284 | 1.17 | 7.6 | 2.9 | 5.8 | 174.0 | 147 | 65 | 64 | 14 | 57 | 113 | 12 | 0 | 0 | 3 | 14 | 3 | 1 | 3.78 |
| SP | Samardzija, J.Samardzija, Jeff >> | 29 | 2014 | R | 74 | 21 | 21 | 9 | 7 | 5.19 | .310 | 1.33 | 9.4 | 2.6 | 8.4 | 130.0 | 136 | 76 | 75 | 23 | 37 | 121 | 3 | 0 | 0 | 2 | 8 | 2 | 2 | 4.34 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 80 | 20 | 20 | 9 | 7 | 4.13 | .301 | 1.27 | 9.2 | 2.3 | 6.8 | 148.1 | 151 | 72 | 68 | 19 | 37 | 112 | 7 | 0 | 0 | 2 | 10 | 4 | 7 | 3.99 |
| SP | Waddell, R.Waddell, Rube # >> | 31 | 1907 | L | 54 | 20 | 20 | 8 | 7 | 4.96 | .329 | 1.44 | 9.5 | 3.5 | 7.4 | 119.2 | 126 | 72 | 66 | 10 | 46 | 98 | 3 | 0 | 0 | 1 | 11 | 4 | 0 | 3.71 |
| RP | Eckersley, D.Eckersley, Dennis >> | 35 | 1989 | R | 90 | 46 | 0 | 2 | 2 | 3.55 | .240 | 0.92 | 6.3 | 2.0 | 7.0 | 63.1 | 44 | 25 | 25 | 2 | 14 | 49 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 2.62 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 81 | 37 | 0 | 3 | 1 | 3.38 | .295 | 1.26 | 7.2 | 4.2 | 9.8 | 45.1 | 36 | 17 | 17 | 2 | 21 | 49 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.80 |
| RP | Madson, R.Madson, Ryan >> | 37 | 2017 | R | 76 | 31 | 0 | 2 | 2 | 3.00 | .312 | 1.33 | 9.0 | 3.0 | 9.5 | 36.0 | 36 | 13 | 12 | 3 | 12 | 38 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.06 |
| RP | Abad, F.Abad, Fernando >> | 28 | 2014 | L | 74 | 16 | 0 | 3 | 3 | 2.18 | .319 | 1.40 | 9.0 | 4.1 | 9.9 | 20.2 | 20 | 5 | 5 | 1 | 9 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 84 | 13 | 0 | 3 | 0 | 0.54 | .123 | 0.42 | 1.7 | 2.3 | 8.4 | 16.2 | 3 | 1 | 1 | 1 | 4 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.69 |
| RP | Scribner, E.Scribner, Evan >> | 29 | 2015 | R | 36 | 11 | 0 | 1 | 0 | 5.00 | .372 | 1.78 | 13.0 | 3.0 | 10.0 | 9.0 | 13 | 5 | 5 | 1 | 3 | 10 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Wendelken, J.Wendelken, J.B. >> | 26 | 2019 | R | 65 | 7 | 0 | 0 | 0 | 5.14 | .323 | 1.43 | 6.4 | 6.4 | 10.3 | 7.0 | 5 | 4 | 4 | 1 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.71 |