| SP | Jimenez, U.Jimenez, Ubaldo >> | 26 | 2010 | R | 55 | 22 | 22 | 6 | 7 | 4.66 | .342 | 1.52 | 9.1 | 4.6 | 5.6 | 143.0 | 145 | 75 | 74 | 21 | 73 | 89 | 4 | 0 | 0 | 2 | 7 | 5 | 6 | 5.30 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 46 | 21 | 21 | 0 | 4 | 6.42 | .373 | 1.77 | 10.3 | 5.8 | 6.5 | 61.2 | 70 | 45 | 44 | 7 | 39 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.02 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 22 | 2010 | R | 41 | 20 | 20 | 10 | 2 | 5.84 | .345 | 1.57 | 9.8 | 4.5 | 8.6 | 101.2 | 110 | 68 | 66 | 12 | 50 | 96 | 0 | 0 | 0 | 0 | 7 | 1 | 3 | 4.16 |
| SP | Gilbreath, L.Gilbreath, Lucas >> | 25 | 2021 | L | 40 | 20 | 20 | 0 | 3 | 10.22 | .422 | 2.19 | 11.4 | 8.3 | 8.3 | 37.0 | 47 | 44 | 42 | 7 | 34 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 6.38 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 70 | 57 | 0 | 10 | 1 | 3.80 | .290 | 1.21 | 6.0 | 5.0 | 11.1 | 68.2 | 45 | 32 | 29 | 5 | 38 | 84 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.21 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 62 | 53 | 0 | 3 | 4 | 3.79 | .305 | 1.31 | 9.0 | 2.9 | 8.1 | 59.1 | 59 | 30 | 25 | 8 | 19 | 53 | 0 | 5 | 5 | 0 | 0 | 0 | 0 | 3.93 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 55 | 49 | 0 | 3 | 3 | 3.60 | .250 | 0.98 | 6.4 | 2.5 | 5.2 | 55.0 | 39 | 22 | 22 | 8 | 15 | 32 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 4.60 |
| RP | McLain, D.McLain, Denny >> | 20 | 1964 | R | 24 | 22 | 0 | 5 | 2 | 4.28 | .348 | 1.57 | 8.7 | 5.7 | 4.6 | 33.2 | 32 | 16 | 16 | 3 | 21 | 17 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 5.15 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 61 | 31 | 0 | 1 | 1 | 5.22 | .313 | 1.36 | 9.0 | 3.4 | 9.3 | 29.1 | 29 | 18 | 17 | 5 | 11 | 30 | 0 | 4 | 3 | 0 | 0 | 0 | 1 | 4.31 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 67 | 45 | 0 | 11 | 2 | 4.62 | .304 | 1.29 | 10.1 | 1.5 | 8.6 | 99.1 | 111 | 53 | 51 | 15 | 17 | 95 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.63 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 40 | 25 | 0 | 1 | 0 | 6.75 | .328 | 1.46 | 9.3 | 3.9 | 7.7 | 28.0 | 29 | 22 | 21 | 5 | 12 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.89 |