| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 100 | 23 | 23 | 11 | 3 | 3.21 | .304 | 1.30 | 8.3 | 3.4 | 8.1 | 154.1 | 142 | 57 | 55 | 7 | 58 | 138 | 2 | 0 | 0 | 0 | 16 | 2 | 2 | 2.97 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 92 | 23 | 23 | 14 | 5 | 3.02 | .305 | 1.30 | 8.8 | 2.9 | 5.5 | 164.0 | 161 | 59 | 55 | 11 | 52 | 100 | 6 | 0 | 0 | 1 | 14 | 3 | 2 | 3.66 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 82 | 24 | 24 | 11 | 7 | 4.52 | .337 | 1.49 | 8.5 | 4.9 | 5.1 | 137.1 | 130 | 78 | 69 | 8 | 75 | 78 | 2 | 0 | 0 | 1 | 14 | 4 | 1 | 4.35 |
| SP | Brown, M.Brown, Mordecai >> | 31 | 1907 | R | 81 | 23 | 23 | 9 | 8 | 4.04 | .329 | 1.45 | 10.0 | 3.1 | 5.3 | 140.1 | 155 | 71 | 63 | 7 | 48 | 83 | 2 | 0 | 0 | 1 | 13 | 3 | 3 | 3.56 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 73 | 24 | 22 | 12 | 9 | 4.11 | .319 | 1.36 | 8.0 | 4.2 | 3.7 | 140.0 | 125 | 73 | 64 | 5 | 65 | 58 | 2 | 0 | 0 | 0 | 11 | 7 | 1 | 4.18 |
| RP | Tepera, R.Tepera, Ryan # >> | 33 | 2021 | R | 95 | 62 | 0 | 2 | 3 | 3.21 | .263 | 1.06 | 7.0 | 2.6 | 7.7 | 84.0 | 65 | 30 | 30 | 11 | 24 | 72 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 3.88 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 87 | 57 | 0 | 3 | 1 | 4.17 | .311 | 1.30 | 7.0 | 4.7 | 5.5 | 54.0 | 42 | 26 | 25 | 3 | 28 | 33 | 0 | 0 | 3 | 0 | 0 | 3 | 3 | 4.22 |
| RP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 81 | 57 | 0 | 2 | 3 | 4.08 | .312 | 1.34 | 7.5 | 4.8 | 10.4 | 70.2 | 58 | 39 | 32 | 6 | 37 | 81 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 3.43 |
| RP | Robertson, D.Robertson, David >> | 37 | 2022 | R | 62 | 33 | 0 | 1 | 0 | 4.19 | .338 | 1.53 | 8.6 | 5.2 | 9.6 | 43.0 | 41 | 20 | 20 | 6 | 25 | 46 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 4.42 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 44 | 0 | 2 | 6 | 4.44 | .321 | 1.42 | 8.4 | 4.5 | 11.3 | 48.2 | 45 | 26 | 24 | 9 | 24 | 60 | 0 | 12 | 11 | 0 | 0 | 0 | 2 | 4.44 |
| SP | Malarkey, J.Malarkey, John >> | 30 | 1902 | R | 30 | 10 | 1 | 2 | 2 | 7.94 | .378 | 1.82 | 11.6 | 4.8 | 3.7 | 17.0 | 22 | 16 | 15 | 5 | 9 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 7.59 |