| SP | Martinez, P.Martinez, Pedro † # >> | 30 | 2001 | R | 87 | 21 | 21 | 14 | 3 | 3.84 | .279 | 1.14 | 7.7 | 2.6 | 9.0 | 147.2 | 126 | 68 | 63 | 14 | 42 | 147 | 4 | 0 | 0 | 3 | 11 | 3 | 2 | 3.16 |
| SP | Steele, E.Steele, Elmer † >> | 22 | 1908 | R | 83 | 21 | 21 | 15 | 2 | 4.29 | .308 | 1.32 | 9.4 | 2.5 | 4.5 | 163.2 | 170 | 80 | 78 | 16 | 46 | 81 | 9 | 0 | 0 | 0 | 9 | 3 | 0 | 4.18 |
| SP | Morgan, C.Morgan, Cy † >> | 29 | 1907 | R | 79 | 20 | 20 | 14 | 4 | 3.06 | .294 | 1.23 | 7.7 | 3.3 | 5.0 | 156.0 | 134 | 56 | 53 | 12 | 58 | 87 | 7 | 0 | 0 | 4 | 13 | 3 | 1 | 4.06 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 95 | 50 | 0 | 6 | 1 | 2.32 | .227 | 0.88 | 5.5 | 2.5 | 9.1 | 66.0 | 40 | 18 | 17 | 3 | 18 | 67 | 0 | 13 | 1 | 0 | 0 | 0 | 0 | 2.38 |
| RP | Brasier, R.Brasier, Ryan >> | 30 | 2018 | R | 79 | 35 | 0 | 1 | 1 | 4.35 | .275 | 1.09 | 8.6 | 1.3 | 5.9 | 41.1 | 39 | 23 | 20 | 2 | 6 | 27 | 0 | 7 | 1 | 0 | 0 | 2 | 1 | 2.90 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 77 | 21 | 0 | 2 | 0 | 2.79 | .326 | 1.40 | 7.1 | 5.7 | 10.9 | 19.1 | 15 | 7 | 6 | 2 | 12 | 23 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Uehara, K.Uehara, Koji >> | 41 | 2016 | R | 56 | 11 | 0 | 1 | 3 | 12.10 | .383 | 1.86 | 14.0 | 4.0 | 15.0 | 9.2 | 14 | 13 | 13 | 5 | 4 | 15 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 8.22 |
| SP | O'Brien, B.O'Brien, Buck >> | 29 | 1911 | R | 69 | 4 | 0 | 2 | 0 | 5.63 | .455 | 2.50 | 12.4 | 10.1 | 7.9 | 8.0 | 11 | 5 | 5 | 1 | 9 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.25 |