| SP | Hamels, C.Hamels, Cole >> | 33 | 2011 | L | 78 | 15 | 15 | 4 | 9 | 4.72 | .308 | 1.33 | 9.3 | 2.7 | 7.1 | 89.2 | 92 | 53 | 47 | 18 | 27 | 70 | 2 | 0 | 0 | 0 | 8 | 1 | 0 | 5.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 36 | 2016 | R | 76 | 14 | 14 | 3 | 7 | 5.95 | .350 | 1.58 | 10.0 | 4.3 | 6.0 | 78.2 | 87 | 54 | 52 | 15 | 37 | 52 | 1 | 0 | 0 | 1 | 5 | 3 | 2 | 5.71 |
| SP | Zambrano, C.Zambrano, Carlos >> | 25 | 2006 | R | 55 | 14 | 14 | 7 | 1 | 2.23 | .285 | 1.18 | 6.5 | 4.1 | 7.1 | 97.0 | 70 | 25 | 24 | 6 | 44 | 77 | 0 | 0 | 0 | 0 | 13 | 2 | 1 | 3.64 |
| SP | Dempster, R.Dempster, Ryan >> | 33 | 2008 | R | 50 | 14 | 14 | 7 | 3 | 3.30 | .301 | 1.26 | 7.4 | 3.9 | 6.4 | 87.1 | 72 | 34 | 32 | 8 | 38 | 62 | 1 | 0 | 0 | 0 | 10 | 3 | 3 | 4.18 |
| RP | Chapman, A.Chapman, Aroldis >> | 34 | 2014 | L | 97 | 43 | 0 | 1 | 0 | 3.05 | .299 | 1.17 | 6.2 | 4.5 | 9.7 | 38.1 | 26 | 14 | 13 | 1 | 19 | 41 | 0 | 2 | 1 | 0 | 0 | 4 | 4 | 3.00 |
| RP | Givens, M.Givens, Mychal >> | 34 | 2015 | R | 73 | 39 | 0 | 1 | 0 | 2.22 | .272 | 1.07 | 6.8 | 3.1 | 7.2 | 44.2 | 33 | 13 | 11 | 5 | 15 | 35 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 4.05 |
| RP | Samardzija, J.Samardzija, Jeff >> | 31 | 2011 | R | 71 | 36 | 0 | 4 | 3 | 4.19 | .356 | 1.66 | 9.0 | 6.2 | 8.8 | 38.2 | 38 | 18 | 18 | 7 | 26 | 37 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.50 |
| RP | Edwards, C.Edwards, Carl >> | 36 | 2017 | R | 69 | 29 | 0 | 2 | 2 | 3.42 | .282 | 1.14 | 6.2 | 4.2 | 10.7 | 26.1 | 18 | 11 | 10 | 0 | 12 | 31 | 0 | 5 | 1 | 0 | 0 | 1 | 3 | 2.12 |
| RP | Guzman, A.Guzman, Angel >> | 31 | 2009 | R | 66 | 18 | 0 | 1 | 1 | 1.35 | .241 | 0.90 | 6.8 | 1.4 | 6.8 | 20.0 | 15 | 3 | 3 | 0 | 3 | 15 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.10 |
| RP | Marshall, S.Marshall, Sean >> | 32 | 2010 | L | 61 | 34 | 0 | 1 | 0 | 1.29 | .267 | 1.05 | 7.3 | 2.1 | 9.4 | 21.0 | 17 | 3 | 3 | 1 | 5 | 22 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.38 |