| SP | Cueto, J.Cueto, Johnny >> | 34 | 2014 | R | 80 | 23 | 23 | 9 | 8 | 4.21 | .294 | 1.22 | 7.2 | 3.8 | 7.7 | 143.1 | 114 | 69 | 67 | 18 | 61 | 123 | 4 | 0 | 0 | 0 | 13 | 4 | 3 | 4.28 |
| SP | Keuchel, D.Keuchel, Dallas >> | 34 | 2015 | L | 68 | 23 | 23 | 12 | 6 | 3.55 | .263 | 1.06 | 7.9 | 1.7 | 7.9 | 157.1 | 137 | 69 | 62 | 20 | 30 | 138 | 3 | 0 | 0 | 2 | 17 | 1 | 0 | 3.49 |
| SP | Shields, J.Shields, James >> | 33 | 2011 | R | 63 | 23 | 23 | 7 | 13 | 4.84 | .318 | 1.38 | 9.2 | 3.3 | 7.7 | 148.2 | 151 | 84 | 80 | 21 | 54 | 126 | 4 | 0 | 0 | 1 | 11 | 3 | 0 | 4.30 |
| SP | Giolito, L.Giolito, Lucas >> | 37 | 2020 | R | 60 | 23 | 23 | 13 | 8 | 4.28 | .286 | 1.17 | 8.0 | 2.6 | 8.6 | 147.1 | 130 | 76 | 70 | 15 | 42 | 141 | 3 | 0 | 0 | 2 | 11 | 5 | 4 | 3.37 |
| CL | Robertson, D.Robertson, David >> | 29 | 2011 | R | 92 | 29 | 0 | 1 | 1 | 1.98 | .226 | 0.88 | 4.7 | 3.3 | 11.0 | 27.1 | 14 | 6 | 6 | 0 | 10 | 33 | 0 | 25 | 3 | 0 | 0 | 0 | 1 | 1.67 |
| SU | Avilan, L.Avilan, Luis >> | 28 | 2013 | L | 89 | 35 | 0 | 1 | 1 | 2.52 | .258 | 1.04 | 8.3 | 1.2 | 7.2 | 39.1 | 36 | 11 | 11 | 4 | 5 | 31 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 3.13 |
| RP | Santos, S.Santos, Sergio >> | 30 | 2011 | R | 81 | 53 | 0 | 1 | 2 | 4.34 | .306 | 1.30 | 7.9 | 4.0 | 7.5 | 47.2 | 41 | 23 | 23 | 3 | 21 | 39 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.57 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 71 | 21 | 0 | 1 | 2 | 5.65 | .338 | 1.53 | 10.3 | 3.9 | 10.3 | 14.1 | 16 | 11 | 9 | 3 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.79 |
| RP | Herrera, K.Herrera, Kelvin >> | 34 | 2016 | R | 57 | 37 | 0 | 2 | 4 | 5.81 | .350 | 1.61 | 11.9 | 2.6 | 7.8 | 31.0 | 41 | 25 | 20 | 6 | 9 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.65 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 46 | 27 | 0 | 1 | 1 | 4.88 | .327 | 1.42 | 10.5 | 2.3 | 7.9 | 24.0 | 28 | 13 | 13 | 3 | 6 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.75 |