| SP | Cueto, J.Cueto, Johnny >> | 36 | 2014 | R | 71 | 14 | 14 | 6 | 5 | 3.53 | .297 | 1.22 | 6.9 | 4.2 | 7.2 | 91.2 | 70 | 36 | 36 | 9 | 42 | 73 | 1 | 0 | 0 | 1 | 9 | 4 | 2 | 4.20 |
| SP | Danks, J.Danks, John # >> | 29 | 2010 | L | 69 | 14 | 14 | 4 | 8 | 4.73 | .325 | 1.40 | 8.5 | 4.2 | 7.2 | 99.0 | 93 | 52 | 52 | 12 | 46 | 79 | 2 | 0 | 0 | 0 | 6 | 4 | 1 | 4.49 |
| SP | Keuchel, D.Keuchel, Dallas >> | 36 | 2015 | L | 67 | 14 | 14 | 7 | 4 | 3.17 | .282 | 1.11 | 7.4 | 2.6 | 6.9 | 96.2 | 79 | 34 | 34 | 7 | 28 | 74 | 2 | 0 | 0 | 1 | 10 | 7 | 1 | 3.50 |
| SP | Shields, J.Shields, James >> | 35 | 2011 | R | 62 | 14 | 14 | 6 | 6 | 3.79 | .296 | 1.22 | 7.9 | 3.2 | 6.7 | 99.2 | 87 | 42 | 42 | 12 | 35 | 74 | 2 | 0 | 0 | 1 | 10 | 4 | 2 | 4.26 |
| SU | Robertson, D.Robertson, David >> | 31 | 2011 | R | 91 | 27 | 0 | 1 | 0 | 1.63 | .202 | 0.76 | 4.3 | 2.7 | 10.0 | 27.2 | 13 | 5 | 5 | 2 | 8 | 30 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.63 |
| RP | Avilan, L.Avilan, Luis >> | 30 | 2013 | L | 89 | 30 | 0 | 3 | 0 | 1.93 | .263 | 1.07 | 6.3 | 3.5 | 5.1 | 23.1 | 16 | 5 | 5 | 1 | 9 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Santos, S.Santos, Sergio >> | 32 | 2011 | R | 82 | 26 | 0 | 2 | 0 | 4.01 | .237 | 0.89 | 6.0 | 2.3 | 8.6 | 24.2 | 16 | 11 | 11 | 1 | 6 | 23 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.50 |
| RP | Thornton, M.Thornton, Matt >> | 34 | 2008 | L | 53 | 14 | 0 | 0 | 0 | 3.38 | .284 | 1.19 | 8.4 | 2.3 | 7.3 | 16.0 | 15 | 6 | 6 | 3 | 4 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.56 |
| SP | Giolito, L.Giolito, Lucas >> | 39 | 2020 | R | 53 | 10 | 0 | 1 | 1 | 5.48 | .326 | 1.45 | 8.1 | 5.1 | 10.7 | 21.1 | 19 | 13 | 13 | 3 | 12 | 25 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.19 |