| SP | Cushman, E.Cushman, Ed >> | 32 | 1884 | L | 100 | 13 | 13 | 6 | 2 | 4.11 | .312 | 1.28 | 8.9 | 2.6 | 8.7 | 85.1 | 84 | 42 | 39 | 9 | 25 | 82 | 2 | 0 | 0 | 1 | 6 | 7 | 0 | 3.58 |
| SP | Coveleski, H.Coveleski, Harry >> | 21 | 1907 | L | 91 | 8 | 7 | 3 | 0 | 4.10 | .313 | 1.37 | 10.0 | 2.4 | 4.1 | 37.1 | 41 | 19 | 17 | 6 | 10 | 17 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.00 |
| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 92 | 12 | 12 | 3 | 4 | 4.38 | .293 | 1.21 | 9.0 | 1.9 | 9.5 | 84.1 | 84 | 52 | 41 | 13 | 18 | 89 | 1 | 0 | 0 | 0 | 5 | 3 | 1 | 3.64 |
| SP | Bauer, T.Bauer, Trevor >> | 29 | 2020 | R | 91 | 13 | 13 | 6 | 6 | 5.99 | .356 | 1.60 | 10.3 | 4.2 | 10.2 | 70.2 | 80 | 51 | 47 | 11 | 33 | 79 | 0 | 0 | 0 | 0 | 5 | 4 | 5 | 4.37 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 28 | 2022 | R | 82 | 22 | 0 | 3 | 4 | 4.15 | .284 | 1.19 | 8.3 | 2.4 | 11.4 | 26.0 | 24 | 13 | 12 | 8 | 7 | 33 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 5.27 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 94 | 22 | 0 | 2 | 0 | 3.33 | .247 | 0.99 | 7.1 | 1.9 | 8.6 | 24.1 | 19 | 9 | 9 | 4 | 5 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.88 |
| RP | de los Santos, V.de los Santos, Valerio >> | 26 | 1998 | L | 79 | 11 | 0 | 1 | 1 | 2.70 | .254 | 1.02 | 5.6 | 3.9 | 6.2 | 16.2 | 10 | 7 | 5 | 0 | 7 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.94 |
| RP | Sanchez, A.Sanchez, Aaron >> | 21 | 2014 | R | 80 | 6 | 0 | 1 | 0 | 6.00 | .333 | 1.50 | 9.0 | 4.5 | 4.5 | 6.0 | 6 | 5 | 4 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.67 |
| RP | Jansen, K.Jansen, Kenley >> | 29 | 2017 | R | 52 | 4 | 0 | 0 | 0 | 6.00 | .500 | 2.67 | 21.0 | 3.0 | 12.0 | 3.0 | 7 | 3 | 2 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.33 |
| SU | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 85 | 26 | 0 | 1 | 0 | 0.99 | .196 | 0.73 | 3.3 | 3.3 | 8.3 | 27.1 | 10 | 5 | 3 | 2 | 10 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.22 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 83 | 8 | 8 | 1 | 2 | 8.65 | .411 | 2.10 | 12.4 | 6.6 | 8.5 | 34.1 | 47 | 33 | 33 | 9 | 25 | 32 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.76 |
| SP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 95 | 20 | 2 | 6 | 1 | 5.58 | .333 | 1.47 | 11.1 | 2.4 | 9.6 | 30.2 | 37 | 22 | 19 | 4 | 8 | 32 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.50 |
| SP | McDowell, J.McDowell, Jack >> | 21 | 1987 | R | 80 | 4 | 2 | 1 | 1 | 5.75 | .351 | 1.57 | 11.7 | 2.7 | 6.8 | 20.1 | 26 | 15 | 13 | 3 | 6 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |