| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 61 | 26 | 26 | 9 | 12 | 5.05 | .339 | 1.51 | 8.9 | 4.7 | 6.6 | 160.1 | 158 | 95 | 90 | 25 | 84 | 118 | 4 | 0 | 0 | 1 | 13 | 5 | 4 | 5.23 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 58 | 26 | 26 | 12 | 12 | 4.65 | .313 | 1.36 | 8.4 | 3.8 | 7.5 | 170.1 | 159 | 91 | 88 | 32 | 72 | 142 | 2 | 0 | 0 | 0 | 13 | 2 | 2 | 5.08 |
| SP | Oswalt, R.Oswalt, Roy # >> | 33 | 2010 | R | 54 | 25 | 25 | 11 | 12 | 5.47 | .320 | 1.38 | 9.5 | 2.9 | 6.3 | 154.2 | 163 | 94 | 94 | 29 | 50 | 108 | 1 | 0 | 0 | 0 | 12 | 5 | 1 | 5.12 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 69 | 0 | 0 | 4 | 3.13 | .299 | 1.22 | 7.6 | 3.3 | 8.6 | 92.0 | 78 | 32 | 32 | 7 | 34 | 88 | 0 | 5 | 1 | 0 | 0 | 6 | 2 | 3.38 |
| RP | Valverde, J.Valverde, Jose # >> | 24 | 2003 | R | 62 | 69 | 0 | 2 | 2 | 5.58 | .318 | 1.39 | 7.2 | 5.4 | 9.0 | 80.2 | 64 | 50 | 50 | 9 | 48 | 80 | 0 | 8 | 2 | 0 | 0 | 1 | 1 | 4.30 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 54 | 51 | 0 | 2 | 2 | 5.10 | .321 | 1.40 | 9.8 | 2.9 | 10.1 | 60.0 | 65 | 34 | 34 | 11 | 19 | 67 | 0 | 7 | 2 | 0 | 0 | 1 | 4 | 4.15 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 41 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |