| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 27 | 27 | 4 | 12 | 4.91 | .314 | 1.36 | 9.8 | 2.5 | 10.4 | 179.2 | 194 | 105 | 98 | 30 | 50 | 206 | 3 | 0 | 0 | 0 | 12 | 3 | 6 | 3.77 |
| SP | Hunter, C.Hunter, Catfish † # >> | 26 | 1972 | R | 84 | 27 | 27 | 10 | 10 | 4.75 | .311 | 1.34 | 8.7 | 3.4 | 6.0 | 189.1 | 182 | 101 | 100 | 29 | 71 | 125 | 8 | 0 | 0 | 0 | 9 | 3 | 5 | 4.85 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 69 | 26 | 26 | 10 | 13 | 4.30 | .303 | 1.29 | 9.3 | 2.3 | 6.0 | 196.2 | 202 | 95 | 94 | 31 | 51 | 131 | 11 | 0 | 0 | 1 | 13 | 4 | 3 | 4.56 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 26 | 26 | 9 | 8 | 4.69 | .318 | 1.37 | 8.2 | 4.1 | 9.7 | 128.2 | 117 | 67 | 67 | 19 | 59 | 138 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 4.25 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 57 | 24 | 24 | 9 | 11 | 5.84 | .337 | 1.52 | 9.3 | 4.5 | 8.8 | 141.2 | 145 | 96 | 92 | 31 | 70 | 138 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 5.41 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 67 | 0 | 4 | 4 | 2.25 | .305 | 1.25 | 7.4 | 3.8 | 9.9 | 92.0 | 76 | 26 | 23 | 9 | 39 | 101 | 0 | 3 | 4 | 0 | 0 | 6 | 2 | 3.54 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 56 | 0 | 2 | 4 | 3.38 | .290 | 1.23 | 6.9 | 4.2 | 10.8 | 69.1 | 53 | 30 | 26 | 8 | 32 | 83 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 3.49 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 51 | 38 | 0 | 4 | 1 | 4.20 | .311 | 1.30 | 8.1 | 3.8 | 8.8 | 40.2 | 36 | 19 | 19 | 5 | 17 | 39 | 0 | 3 | 1 | 0 | 0 | 2 | 7 | 4.10 |
| RP | Smith, D.Smith, Dave # >> | 32 | 1987 | R | 45 | 34 | 0 | 1 | 3 | 5.45 | .307 | 1.27 | 9.5 | 2.1 | 10.6 | 34.2 | 36 | 21 | 21 | 9 | 8 | 40 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 4.97 |
| SP | Candelaria, J.Candelaria, John >> | 33 | 1986 | L | 55 | 4 | 1 | 1 | 2 | 7.84 | .392 | 1.94 | 14.4 | 3.6 | 3.6 | 10.1 | 16 | 9 | 9 | 3 | 4 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 7.30 |
| SP | Norris, M.Norris, Mike >> | 25 | 1980 | R | 47 | 17 | 0 | 2 | 1 | 2.83 | .281 | 1.14 | 7.7 | 2.6 | 6.4 | 35.0 | 30 | 11 | 11 | 4 | 10 | 25 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.00 |