| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 72 | 13 | 13 | 3 | 4 | 4.12 | .335 | 1.51 | 10.0 | 3.7 | 6.8 | 78.2 | 87 | 38 | 36 | 12 | 32 | 59 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.72 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 13 | 13 | 3 | 9 | 5.73 | .357 | 1.64 | 11.7 | 3.2 | 7.8 | 81.2 | 105 | 53 | 52 | 18 | 29 | 70 | 3 | 0 | 0 | 0 | 5 | 2 | 0 | 5.31 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 61 | 13 | 13 | 3 | 8 | 4.97 | .350 | 1.59 | 10.3 | 4.1 | 8.0 | 88.2 | 101 | 57 | 49 | 16 | 40 | 78 | 3 | 0 | 0 | 0 | 3 | 2 | 4 | 5.02 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 35 | 0 | 1 | 1 | 3.44 | .307 | 1.31 | 9.0 | 2.9 | 9.9 | 49.2 | 49 | 22 | 19 | 6 | 16 | 54 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.43 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 78 | 34 | 0 | 1 | 1 | 2.82 | .283 | 1.19 | 7.2 | 3.7 | 10.8 | 44.2 | 35 | 14 | 14 | 3 | 18 | 53 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 2.70 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 74 | 27 | 0 | 1 | 4 | 8.13 | .362 | 1.66 | 12.7 | 2.7 | 8.7 | 27.2 | 38 | 25 | 25 | 10 | 8 | 26 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 6.89 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 22 | 0 | 1 | 0 | 4.64 | .319 | 1.41 | 8.6 | 4.3 | 13.3 | 21.1 | 20 | 11 | 11 | 3 | 10 | 31 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.33 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 10 | 0 | 2 | 1 | 5.87 | .313 | 1.30 | 7.8 | 4.2 | 10.8 | 15.1 | 13 | 10 | 10 | 2 | 7 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.93 |