| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 28 | 28 | 11 | 12 | 4.44 | .318 | 1.39 | 9.0 | 3.5 | 10.0 | 164.1 | 164 | 85 | 81 | 16 | 64 | 183 | 0 | 0 | 0 | 0 | 16 | 2 | 4 | 3.24 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 28 | 28 | 7 | 10 | 6.07 | .345 | 1.57 | 10.2 | 3.8 | 9.1 | 138.0 | 157 | 96 | 93 | 39 | 59 | 139 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 5.99 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 77 | 26 | 26 | 10 | 6 | 3.66 | .288 | 1.20 | 8.2 | 2.7 | 6.5 | 159.2 | 144 | 66 | 65 | 16 | 47 | 114 | 2 | 0 | 0 | 1 | 18 | 3 | 2 | 3.82 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 27 | 26 | 8 | 9 | 5.30 | .316 | 1.37 | 8.9 | 3.4 | 5.8 | 151.0 | 150 | 94 | 89 | 31 | 57 | 97 | 6 | 0 | 0 | 0 | 10 | 2 | 6 | 5.56 |
| SP | Hamels, C.Hamels, Cole † >> | 28 | 2011 | L | 63 | 24 | 24 | 10 | 7 | 3.87 | .311 | 1.34 | 8.8 | 3.4 | 7.0 | 144.1 | 140 | 73 | 62 | 22 | 54 | 112 | 0 | 0 | 0 | 0 | 14 | 1 | 2 | 4.58 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 60 | 0 | 5 | 2 | 3.67 | .299 | 1.28 | 9.8 | 1.7 | 9.3 | 54.0 | 59 | 23 | 22 | 5 | 10 | 56 | 0 | 6 | 3 | 0 | 0 | 0 | 2 | 2.69 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 46 | 0 | 0 | 0 | 5.11 | .315 | 1.35 | 9.2 | 2.9 | 10.0 | 37.0 | 38 | 21 | 21 | 10 | 12 | 41 | 0 | 6 | 0 | 0 | 0 | 1 | 2 | 5.35 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 74 | 76 | 0 | 3 | 2 | 2.72 | .271 | 1.11 | 7.3 | 2.7 | 8.5 | 53.0 | 43 | 16 | 16 | 5 | 16 | 50 | 0 | 7 | 1 | 0 | 0 | 0 | 4 | 3.25 |