| SP | Zito, B.Zito, Barry # $ >> | 29 | 2000 | L | 100 | 16 | 16 | 6 | 5 | 5.00 | .320 | 1.33 | 8.8 | 3.3 | 7.7 | 102.2 | 100 | 59 | 57 | 13 | 37 | 87 | 2 | 0 | 0 | 0 | 8 | 8 | 1 | 4.27 |
| SP | Harden, R.Harden, Rich $ >> | 26 | 2003 | R | 89 | 16 | 16 | 7 | 8 | 4.48 | .285 | 1.13 | 7.6 | 2.6 | 5.7 | 96.1 | 81 | 48 | 48 | 11 | 28 | 61 | 1 | 0 | 0 | 0 | 8 | 6 | 4 | 4.28 |
| SP | Lyon, B.Lyon, Brandon $ >> | 28 | 2001 | R | 88 | 16 | 16 | 8 | 4 | 3.82 | .277 | 1.12 | 7.6 | 2.5 | 6.2 | 117.2 | 99 | 52 | 50 | 14 | 33 | 80 | 3 | 0 | 0 | 1 | 9 | 3 | 0 | 4.11 |
| SP | Lilly, T.Lilly, Ted # $ >> | 31 | 2002 | L | 88 | 16 | 16 | 3 | 3 | 5.30 | .323 | 1.38 | 9.6 | 2.9 | 6.1 | 74.2 | 79 | 51 | 44 | 13 | 24 | 50 | 0 | 0 | 0 | 0 | 3 | 4 | 3 | 5.07 |
| SP | Hudson, T.Hudson, Tim # $ >> | 32 | 1999 | R | 81 | 15 | 15 | 4 | 5 | 5.38 | .337 | 1.45 | 10.3 | 2.9 | 11.7 | 93.2 | 106 | 61 | 56 | 13 | 30 | 121 | 1 | 0 | 0 | 1 | 6 | 7 | 1 | 3.41 |
| RP | Osuna, A.Osuna, Antonio $ >> | 34 | 1996 | R | 88 | 39 | 0 | 3 | 4 | 4.12 | .321 | 1.40 | 10.3 | 2.5 | 5.9 | 43.2 | 49 | 20 | 20 | 5 | 12 | 28 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 4.12 |
| RP | Heredia, F.Heredia, Felix $ >> | 32 | 1997 | L | 89 | 42 | 0 | 1 | 1 | 4.11 | .335 | 1.49 | 7.5 | 5.9 | 7.7 | 35.0 | 29 | 17 | 16 | 1 | 23 | 30 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.71 |
| RP | Reyes, D.Reyes, Dennys $ >> | 30 | 2006 | L | 80 | 21 | 0 | 0 | 0 | 2.95 | .236 | 0.87 | 7.0 | 1.0 | 7.0 | 18.1 | 14 | 6 | 6 | 4 | 2 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.83 |
| CL | Street, H.Street, Huston # $ >> | 24 | 2005 | R | 94 | 30 | 0 | 2 | 6 | 5.64 | .295 | 1.25 | 8.4 | 3.0 | 8.4 | 30.1 | 28 | 20 | 19 | 5 | 10 | 28 | 0 | 18 | 2 | 0 | 0 | 0 | 0 | 4.30 |
| SP | Kendrick, K.Kendrick, Kyle >> | 23 | 2007 | R | 34 | 14 | 0 | 1 | 2 | 3.81 | .329 | 1.42 | 10.0 | 2.8 | 6.7 | 54.1 | 60 | 24 | 23 | 6 | 17 | 40 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.07 |