| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 13 | 13 | 5 | 4 | 3.76 | .265 | 1.06 | 6.8 | 2.9 | 8.8 | 88.2 | 66 | 38 | 37 | 13 | 28 | 86 | 1 | 0 | 0 | 1 | 6 | 2 | 0 | 3.99 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 12 | 12 | 4 | 5 | 3.98 | .300 | 1.24 | 8.3 | 2.9 | 6.5 | 92.2 | 85 | 45 | 41 | 13 | 30 | 66 | 3 | 0 | 0 | 0 | 7 | 4 | 0 | 4.51 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 12 | 12 | 5 | 7 | 4.35 | .266 | 1.09 | 7.1 | 2.7 | 5.5 | 82.2 | 65 | 41 | 40 | 11 | 25 | 50 | 2 | 0 | 0 | 1 | 6 | 0 | 1 | 4.44 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 33 | 0 | 2 | 1 | 3.40 | .294 | 1.23 | 6.9 | 4.3 | 12.6 | 42.1 | 32 | 16 | 16 | 4 | 20 | 59 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 2.93 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 27 | 0 | 2 | 1 | 1.31 | .254 | 0.93 | 6.4 | 2.1 | 7.7 | 34.1 | 24 | 5 | 5 | 1 | 8 | 29 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 2.65 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 19 | 0 | 2 | 2 | 2.39 | .210 | 0.76 | 5.2 | 1.7 | 9.3 | 26.1 | 15 | 7 | 7 | 2 | 5 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.62 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 68 | 15 | 0 | 0 | 1 | 3.00 | .308 | 1.20 | 5.4 | 5.4 | 10.8 | 15.0 | 9 | 5 | 5 | 2 | 9 | 18 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.53 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 67 | 13 | 0 | 2 | 1 | 0.71 | .296 | 1.18 | 9.0 | 2.3 | 5.3 | 12.2 | 12 | 1 | 1 | 0 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.83 |