| SP | Kershaw, C.Kershaw, Clayton >> | 24 | 2012 | L | 100 | 17 | 17 | 11 | 2 | 2.27 | .247 | 0.97 | 6.4 | 2.4 | 9.9 | 122.2 | 87 | 31 | 31 | 10 | 32 | 134 | 1 | 0 | 0 | 0 | 14 | 2 | 3 | 2.70 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 68 | 17 | 17 | 11 | 4 | 3.73 | .290 | 1.21 | 9.3 | 1.8 | 8.7 | 108.2 | 111 | 47 | 45 | 17 | 21 | 104 | 1 | 0 | 0 | 0 | 13 | 1 | 3 | 3.73 |
| SP | Capuano, C.Capuano, Chris # >> | 34 | 2012 | L | 48 | 17 | 17 | 10 | 4 | 3.95 | .282 | 1.17 | 8.4 | 2.2 | 7.7 | 86.2 | 80 | 39 | 38 | 11 | 21 | 74 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 3.71 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 27 | 2007 | R | 36 | 14 | 14 | 5 | 5 | 4.56 | .313 | 1.31 | 8.7 | 3.0 | 8.1 | 71.0 | 69 | 38 | 36 | 13 | 24 | 64 | 0 | 0 | 0 | 0 | 5 | 4 | 3 | 4.76 |
| SP | Billingsley, C.Billingsley, Chad >> | 28 | 2012 | R | 25 | 13 | 13 | 4 | 4 | 4.16 | .314 | 1.36 | 8.7 | 3.5 | 7.7 | 67.0 | 65 | 31 | 31 | 10 | 26 | 57 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.45 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 98 | 35 | 0 | 0 | 0 | 1.15 | .223 | 0.86 | 5.5 | 2.3 | 11.6 | 31.1 | 19 | 6 | 4 | 0 | 8 | 40 | 0 | 31 | 0 | 0 | 0 | 0 | 0 | 1.19 |
| RP | Jansen, K.Jansen, Kenley # >> | 24 | 2012 | R | 96 | 48 | 0 | 0 | 0 | 4.07 | .281 | 1.15 | 6.8 | 3.8 | 10.5 | 48.2 | 36 | 22 | 22 | 5 | 20 | 56 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 3.33 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 79 | 44 | 0 | 3 | 1 | 4.46 | .292 | 1.21 | 8.5 | 2.5 | 7.5 | 36.1 | 34 | 19 | 18 | 4 | 10 | 30 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 25 | 2007 | R | 80 | 30 | 0 | 5 | 1 | 2.61 | .273 | 1.06 | 5.5 | 4.1 | 8.1 | 31.0 | 19 | 10 | 9 | 4 | 14 | 28 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.42 |
| RP | Belisario, R.Belisario, Ronald >> | 30 | 2012 | R | 77 | 31 | 0 | 0 | 3 | 4.91 | .358 | 1.68 | 9.0 | 6.5 | 8.6 | 25.2 | 25 | 14 | 14 | 2 | 18 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Elbert, S.Elbert, Scott >> | 27 | 2012 | L | 37 | 18 | 0 | 1 | 0 | 2.25 | .310 | 1.30 | 7.7 | 4.1 | 10.4 | 20.0 | 17 | 5 | 5 | 1 | 9 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.85 |
| SP | Harang, A.Harang, Aaron >> | 34 | 2012 | R | 20 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |