| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 24 | 24 | 9 | 10 | 4.01 | .284 | 1.16 | 7.6 | 2.9 | 8.5 | 150.1 | 127 | 70 | 67 | 20 | 48 | 141 | 3 | 0 | 0 | 1 | 13 | 4 | 2 | 3.89 |
| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 95 | 24 | 24 | 9 | 11 | 3.90 | .289 | 1.21 | 8.1 | 2.8 | 9.6 | 159.1 | 143 | 72 | 69 | 25 | 49 | 169 | 1 | 0 | 0 | 0 | 17 | 2 | 2 | 3.88 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 92 | 23 | 23 | 4 | 13 | 6.83 | .343 | 1.55 | 10.8 | 3.2 | 8.8 | 117.1 | 140 | 91 | 89 | 30 | 42 | 114 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 5.51 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 90 | 23 | 23 | 6 | 8 | 5.01 | .336 | 1.49 | 9.9 | 3.5 | 9.2 | 125.2 | 138 | 80 | 70 | 24 | 49 | 128 | 0 | 0 | 0 | 0 | 9 | 4 | 5 | 4.72 |
| CL | Doolittle, S.Doolittle, Sean >> | 27 | 2014 | L | 93 | 59 | 0 | 3 | 6 | 3.81 | .256 | 1.02 | 8.0 | 1.2 | 9.4 | 75.2 | 67 | 33 | 32 | 12 | 10 | 78 | 0 | 20 | 5 | 0 | 0 | 1 | 0 | 3.44 |
| SU | Miller, A.Miller, Andrew >> | 30 | 2015 | L | 89 | 66 | 0 | 2 | 3 | 2.46 | .245 | 0.95 | 5.1 | 3.5 | 9.6 | 80.1 | 45 | 22 | 22 | 4 | 31 | 85 | 0 | 5 | 3 | 0 | 0 | 2 | 1 | 2.76 |
| SP | Siebert, S.Siebert, Sonny >> | 28 | 1965 | R | 78 | 28 | 0 | 5 | 2 | 2.40 | .277 | 1.13 | 6.4 | 3.9 | 10.3 | 48.2 | 34 | 13 | 13 | 5 | 21 | 55 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.44 |