| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 89 | 33 | 33 | 12 | 13 | 4.43 | .315 | 1.35 | 9.4 | 2.8 | 6.9 | 223.2 | 234 | 127 | 110 | 37 | 69 | 172 | 2 | 0 | 0 | 0 | 18 | 6 | 2 | 4.62 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 33 | 33 | 8 | 19 | 5.30 | .333 | 1.48 | 10.3 | 3.1 | 6.3 | 224.1 | 257 | 146 | 132 | 41 | 76 | 157 | 0 | 0 | 0 | 0 | 13 | 3 | 3 | 5.04 |
| SP | Keisler, R.Keisler, Randy >> | 30 | 2001 | L | 80 | 32 | 32 | 4 | 22 | 5.32 | .331 | 1.45 | 9.4 | 3.7 | 7.0 | 191.1 | 199 | 134 | 113 | 37 | 78 | 148 | 0 | 0 | 0 | 0 | 15 | 7 | 0 | 5.30 |
| SP | Johnson, R.Johnson, Randy >> | 43 | 2005 | L | 66 | 32 | 32 | 4 | 19 | 6.33 | .352 | 1.58 | 10.7 | 3.6 | 6.3 | 172.0 | 204 | 134 | 121 | 39 | 68 | 121 | 0 | 0 | 0 | 0 | 7 | 8 | 2 | 5.87 |
| SP | Weaver, J.Weaver, Jeff >> | 30 | 2002 | R | 71 | 32 | 32 | 11 | 16 | 3.67 | .292 | 1.22 | 8.7 | 2.3 | 6.1 | 193.2 | 186 | 92 | 79 | 23 | 50 | 130 | 0 | 0 | 0 | 0 | 19 | 4 | 3 | 4.04 |
| RP | Choate, R.Choate, Randy >> | 31 | 2001 | L | 94 | 81 | 0 | 2 | 2 | 4.29 | .313 | 1.34 | 8.3 | 3.9 | 7.0 | 77.2 | 71 | 47 | 37 | 14 | 33 | 60 | 0 | 2 | 1 | 0 | 0 | 2 | 6 | 5.17 |
| SU | Contreras, J.Contreras, Jose >> | 35 | 2003 | R | 52 | 74 | 0 | 3 | 10 | 4.32 | .330 | 1.44 | 9.0 | 4.0 | 7.7 | 100.0 | 100 | 54 | 48 | 19 | 44 | 86 | 0 | 4 | 5 | 0 | 0 | 4 | 4 | 5.19 |
| RP | Wickman, B.Wickman, Bob >> | 35 | 2001 | R | 44 | 81 | 0 | 4 | 1 | 5.46 | .345 | 1.53 | 10.6 | 3.3 | 7.3 | 57.2 | 67 | 40 | 35 | 6 | 21 | 46 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 4.02 |
| RP | Reyes, D.Reyes, Dennys >> | 29 | 2002 | L | 51 | 66 | 0 | 5 | 4 | 4.25 | .299 | 1.27 | 8.6 | 3.0 | 7.8 | 82.2 | 78 | 43 | 39 | 20 | 27 | 71 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 5.46 |
| SP | Karstens, J.Karstens, Jeff >> | 24 | 2006 | R | 53 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| CL | Rivera, M.Rivera, Mariano >> | 36 | 2005 | R | 92 | 50 | 0 | 0 | 2 | 3.22 | .283 | 1.12 | 7.6 | 2.7 | 7.8 | 44.2 | 37 | 16 | 16 | 3 | 13 | 38 | 0 | 33 | 4 | 0 | 0 | 3 | 0 | 3.25 |