| SP | Rodon, C.Rodon, Carlos † >> | 28 | 2021 | L | 99 | 34 | 34 | 15 | 12 | 2.62 | .269 | 1.09 | 7.2 | 2.7 | 9.3 | 206.1 | 164 | 60 | 60 | 18 | 61 | 214 | 0 | 0 | 0 | 0 | 22 | 3 | 6 | 2.99 |
| SP | Giolito, L.Giolito, Lucas >> | 26 | 2021 | R | 85 | 34 | 34 | 11 | 10 | 3.97 | .303 | 1.28 | 8.2 | 3.3 | 8.0 | 199.2 | 182 | 91 | 88 | 21 | 74 | 176 | 0 | 0 | 0 | 0 | 18 | 5 | 12 | 3.79 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 96 | 123 | 0 | 4 | 3 | 3.43 | .270 | 1.10 | 7.3 | 2.6 | 9.1 | 86.2 | 70 | 33 | 33 | 6 | 25 | 87 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 2.79 |
| RP | Crochet, G.Crochet, Garrett >> | 22 | 2021 | L | 55 | 89 | 0 | 7 | 2 | 3.59 | .285 | 1.20 | 7.5 | 3.4 | 8.1 | 42.2 | 35 | 19 | 17 | 1 | 16 | 38 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 2.64 |
| RP | Bummer, A.Bummer, Aaron >> | 27 | 2021 | L | 59 | 110 | 0 | 1 | 1 | 2.98 | .261 | 1.06 | 5.6 | 4.0 | 7.0 | 45.1 | 28 | 15 | 15 | 5 | 20 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.22 |
| RP | Kopech, M.Kopech, Michael >> | 25 | 2021 | R | 72 | 88 | 0 | 2 | 1 | 3.05 | .291 | 1.20 | 7.8 | 3.0 | 7.2 | 65.0 | 56 | 22 | 22 | 7 | 22 | 52 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 3.91 |
| RP | Fisher, E.Fisher, Eddie >> | 28 | 1964 | R | 85 | 29 | 0 | 2 | 0 | 2.93 | .287 | 1.21 | 8.1 | 3.0 | 5.7 | 30.2 | 27 | 12 | 10 | 4 | 10 | 19 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.47 |
| RP | Lopez, R.Lopez, Reynaldo >> | 27 | 2021 | R | 86 | 62 | 0 | 2 | 2 | 4.12 | .306 | 1.32 | 8.5 | 3.5 | 7.6 | 39.1 | 37 | 19 | 18 | 4 | 15 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.79 |
| RP | DeLeon, J.DeLeon, Jose >> | 34 | 1994 | R | 66 | 27 | 0 | 1 | 4 | 4.71 | .252 | 1.01 | 5.8 | 3.5 | 8.7 | 28.2 | 18 | 15 | 15 | 2 | 11 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.18 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 42 | 1964 | R | 84 | 22 | 0 | 4 | 2 | 5.76 | .342 | 1.52 | 9.4 | 4.3 | 5.8 | 25.0 | 26 | 18 | 16 | 4 | 12 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.36 |
| SU | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 99 | 55 | 0 | 1 | 6 | 3.73 | .283 | 1.18 | 9.0 | 1.8 | 10.1 | 50.2 | 50 | 22 | 21 | 9 | 10 | 56 | 0 | 15 | 6 | 0 | 0 | 0 | 1 | 3.70 |
| SP | Pizarro, J.Pizarro, Juan >> | 27 | 1964 | L | 84 | 35 | 8 | 4 | 4 | 3.81 | .283 | 1.19 | 8.2 | 2.5 | 5.2 | 118.0 | 107 | 51 | 50 | 10 | 33 | 68 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 3.79 |
| SP | Peters, G.Peters, Gary >> | 27 | 1964 | L | 71 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 97 | 69 | 0 | 4 | 7 | 3.44 | .279 | 1.15 | 6.9 | 3.5 | 8.1 | 70.2 | 54 | 28 | 27 | 4 | 27 | 63 | 0 | 31 | 6 | 0 | 0 | 1 | 6 | 3.14 |