| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 90 | 34 | 34 | 14 | 12 | 3.39 | .293 | 1.20 | 7.2 | 3.7 | 7.6 | 220.1 | 175 | 89 | 83 | 20 | 90 | 186 | 3 | 0 | 0 | 0 | 23 | 9 | 7 | 3.84 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 34 | 34 | 13 | 18 | 4.38 | .312 | 1.34 | 7.9 | 4.2 | 8.3 | 193.0 | 169 | 95 | 94 | 26 | 90 | 177 | 0 | 0 | 0 | 0 | 19 | 4 | 2 | 4.38 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 65 | 32 | 25 | 7 | 12 | 4.91 | .325 | 1.43 | 9.1 | 3.8 | 6.3 | 152.0 | 153 | 92 | 83 | 17 | 64 | 107 | 0 | 0 | 0 | 0 | 11 | 3 | 1 | 4.37 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 94 | 33 | 33 | 9 | 16 | 5.04 | .332 | 1.48 | 9.6 | 3.7 | 6.1 | 187.2 | 200 | 116 | 105 | 29 | 77 | 126 | 1 | 0 | 0 | 0 | 18 | 3 | 4 | 4.95 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 98 | 57 | 0 | 2 | 8 | 3.05 | .272 | 1.10 | 5.9 | 4.0 | 11.0 | 59.0 | 39 | 21 | 20 | 5 | 26 | 72 | 0 | 37 | 4 | 0 | 0 | 1 | 5 | 3.03 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 90 | 0 | 8 | 1 | 2.74 | .276 | 1.11 | 6.7 | 3.3 | 9.4 | 82.0 | 61 | 25 | 25 | 7 | 30 | 86 | 0 | 0 | 2 | 0 | 0 | 3 | 4 | 3.22 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 80 | 60 | 0 | 2 | 3 | 3.75 | .278 | 1.11 | 8.3 | 1.8 | 7.0 | 50.1 | 46 | 22 | 21 | 8 | 10 | 39 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.24 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 60 | 87 | 0 | 0 | 1 | 3.78 | .291 | 1.23 | 7.1 | 4.1 | 7.2 | 66.2 | 52 | 33 | 28 | 7 | 30 | 53 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 4.14 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 96 | 57 | 0 | 1 | 1 | 4.23 | .308 | 1.32 | 9.0 | 2.9 | 9.7 | 55.1 | 55 | 31 | 26 | 6 | 18 | 59 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.31 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 89 | 13 | 8 | 1 | 6 | 7.11 | .392 | 1.89 | 11.7 | 5.6 | 5.2 | 50.2 | 65 | 52 | 40 | 10 | 31 | 29 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 6.42 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 56 | 9 | 0 | 0 | 2 | 6.66 | .342 | 1.52 | 10.5 | 3.4 | 6.4 | 24.1 | 28 | 18 | 18 | 5 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.54 |