| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 35 | 35 | 21 | 11 | 3.32 | .278 | 1.12 | 7.5 | 2.6 | 7.6 | 260.1 | 216 | 103 | 96 | 39 | 76 | 219 | 7 | 0 | 0 | 2 | 23 | 8 | 2 | 4.23 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 83 | 0 | 4 | 5 | 3.94 | .268 | 1.09 | 6.6 | 3.2 | 8.8 | 89.0 | 65 | 40 | 39 | 12 | 32 | 87 | 0 | 11 | 4 | 0 | 0 | 1 | 7 | 3.91 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 65 | 0 | 6 | 4 | 2.91 | .326 | 1.43 | 6.6 | 6.3 | 9.2 | 74.1 | 54 | 30 | 24 | 7 | 52 | 76 | 0 | 10 | 4 | 0 | 0 | 2 | 1 | 4.36 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 41 | 0 | 1 | 3 | 3.89 | .306 | 1.30 | 7.2 | 4.6 | 7.7 | 41.2 | 33 | 23 | 18 | 4 | 21 | 35 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 4.17 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 34 | 34 | 15 | 15 | 5.14 | .322 | 1.41 | 8.4 | 4.3 | 5.6 | 236.1 | 220 | 155 | 135 | 37 | 114 | 148 | 4 | 0 | 0 | 1 | 14 | 3 | 4 | 5.27 |
| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 11 | 8 | 2.88 | .271 | 1.09 | 6.8 | 3.0 | 10.4 | 225.1 | 171 | 80 | 72 | 15 | 75 | 261 | 1 | 0 | 0 | 0 | 23 | 5 | 0 | 2.61 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 10 | 13 | 3.75 | .289 | 1.20 | 7.7 | 3.1 | 8.0 | 201.1 | 171 | 98 | 84 | 29 | 70 | 179 | 0 | 0 | 0 | 0 | 17 | 5 | 6 | 4.21 |