| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 99 | 33 | 33 | 7 | 16 | 3.40 | .290 | 1.21 | 8.0 | 2.9 | 9.4 | 227.2 | 202 | 91 | 86 | 24 | 73 | 237 | 6 | 0 | 0 | 2 | 19 | 4 | 5 | 3.30 |
| SP | Martinez, P.Martinez, Pedro >> | 33 | 2004 | R | 89 | 32 | 32 | 6 | 11 | 4.20 | .296 | 1.22 | 7.4 | 3.6 | 8.9 | 203.2 | 167 | 108 | 95 | 25 | 82 | 200 | 1 | 0 | 0 | 0 | 18 | 8 | 4 | 3.96 |
| SP | Maddux, G.Maddux, Greg >> | 38 | 2004 | R | 66 | 32 | 32 | 13 | 15 | 6.22 | .354 | 1.63 | 11.9 | 2.8 | 6.6 | 185.1 | 245 | 130 | 128 | 35 | 57 | 135 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 4.97 |
| SP | Brown, K.Brown, Kevin # >> | 39 | 2004 | R | 53 | 32 | 32 | 7 | 16 | 5.73 | .322 | 1.40 | 9.8 | 2.9 | 5.2 | 183.2 | 200 | 126 | 117 | 31 | 58 | 106 | 1 | 0 | 0 | 0 | 14 | 4 | 4 | 5.06 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 87 | 86 | 0 | 6 | 8 | 4.31 | .342 | 1.53 | 8.6 | 5.3 | 8.7 | 104.1 | 99 | 58 | 50 | 13 | 61 | 101 | 0 | 4 | 7 | 0 | 0 | 3 | 0 | 4.53 |
| RP | Hoffman, T.Hoffman, Trevor >> | 37 | 2004 | R | 86 | 78 | 0 | 5 | 6 | 3.82 | .313 | 1.31 | 9.5 | 2.4 | 8.7 | 94.1 | 99 | 44 | 40 | 12 | 25 | 91 | 0 | 7 | 6 | 0 | 0 | 5 | 1 | 3.68 |
| RP | Colome, J.Colome, Jesus >> | 27 | 2004 | R | 80 | 68 | 0 | 3 | 6 | 3.68 | .292 | 1.19 | 6.9 | 3.9 | 8.2 | 80.2 | 61 | 35 | 33 | 13 | 35 | 73 | 0 | 6 | 3 | 0 | 0 | 4 | 2 | 4.75 |
| RP | Miller, M.Miller, Matt >> | 33 | 2004 | R | 72 | 47 | 0 | 3 | 3 | 2.38 | .274 | 1.11 | 6.5 | 3.6 | 8.0 | 53.0 | 38 | 17 | 14 | 3 | 21 | 47 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.21 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 30 | 2004 | R | 65 | 39 | 0 | 3 | 2 | 2.54 | .277 | 1.13 | 6.8 | 3.3 | 6.7 | 46.0 | 35 | 14 | 13 | 2 | 17 | 34 | 0 | 2 | 1 | 0 | 0 | 1 | 4 | 3.26 |
| SP | Vazquez, J.Vazquez, Javier >> | 28 | 2004 | R | 52 | 23 | 1 | 2 | 0 | 3.52 | .302 | 1.26 | 8.9 | 2.5 | 6.4 | 94.2 | 93 | 39 | 37 | 15 | 26 | 67 | 0 | 1 | 0 | 0 | 0 | 4 | 6 | 4.61 |