| SP | Clemens, R.Clemens, Roger >> | 44 | 2005 | R | 89 | 33 | 33 | 14 | 11 | 3.44 | .292 | 1.21 | 7.6 | 3.4 | 6.4 | 225.0 | 189 | 92 | 86 | 19 | 84 | 160 | 3 | 0 | 0 | 1 | 23 | 6 | 2 | 3.88 |
| SP | Keisler, R.Keisler, Randy >> | 30 | 2001 | L | 85 | 32 | 32 | 10 | 13 | 4.80 | .324 | 1.41 | 9.3 | 3.4 | 7.1 | 174.1 | 180 | 98 | 93 | 37 | 65 | 137 | 1 | 0 | 0 | 0 | 16 | 6 | 0 | 5.41 |
| SP | Pettitte, A.Pettitte, Andy >> | 34 | 2005 | L | 76 | 32 | 32 | 8 | 9 | 5.16 | .307 | 1.32 | 9.6 | 2.3 | 6.7 | 139.2 | 148 | 84 | 80 | 32 | 36 | 104 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 5.32 |
| SP | Mussina, M.Mussina, Mike >> | 38 | 2006 | R | 72 | 32 | 32 | 9 | 10 | 4.96 | .302 | 1.27 | 9.2 | 2.3 | 6.9 | 143.1 | 146 | 85 | 79 | 28 | 36 | 110 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 4.85 |
| RP | Choate, R.Choate, Randy >> | 31 | 2001 | L | 94 | 99 | 0 | 2 | 3 | 3.90 | .282 | 1.14 | 6.9 | 3.4 | 6.7 | 122.1 | 94 | 59 | 53 | 11 | 46 | 91 | 0 | 2 | 4 | 0 | 0 | 4 | 6 | 3.91 |
| RP | Rivera, M.Rivera, Mariano >> | 37 | 2005 | R | 93 | 89 | 0 | 3 | 7 | 3.71 | .277 | 1.12 | 7.3 | 2.8 | 8.5 | 99.1 | 80 | 45 | 41 | 10 | 31 | 93 | 0 | 8 | 5 | 0 | 0 | 3 | 0 | 3.46 |
| RP | Proctor, S.Proctor, Scott >> | 29 | 2006 | R | 71 | 69 | 0 | 3 | 5 | 2.89 | .290 | 1.18 | 8.7 | 1.9 | 7.7 | 84.0 | 81 | 34 | 27 | 4 | 18 | 72 | 0 | 13 | 6 | 0 | 0 | 4 | 0 | 2.69 |
| RP | Wang, C.Wang, Chien-Ming # >> | 26 | 2005 | R | 62 | 43 | 0 | 2 | 10 | 5.27 | .321 | 1.42 | 10.5 | 2.4 | 7.0 | 68.1 | 79 | 46 | 40 | 10 | 18 | 53 | 0 | 9 | 2 | 0 | 0 | 0 | 1 | 4.15 |
| RP | Contreras, J.Contreras, Jose >> | 35 | 2006 | R | 54 | 20 | 0 | 0 | 1 | 6.37 | .378 | 1.79 | 13.0 | 3.4 | 6.8 | 29.2 | 42 | 28 | 21 | 4 | 11 | 22 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.52 |
| RP | Mendoza, R.Mendoza, Ramiro >> | 34 | 2001 | R | 50 | 28 | 0 | 2 | 0 | 2.56 | .288 | 1.19 | 9.2 | 1.7 | 6.4 | 38.2 | 39 | 11 | 11 | 5 | 7 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.92 |
| SP | Weaver, J.Weaver, Jeff >> | 30 | 2002 | R | 68 | 33 | 0 | 5 | 8 | 4.39 | .308 | 1.30 | 9.5 | 2.3 | 6.5 | 158.0 | 166 | 85 | 77 | 19 | 40 | 114 | 0 | 0 | 0 | 0 | 0 | 5 | 4 | 3.97 |