| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 21 | 21 | 13 | 4 | 3.09 | .231 | 0.89 | 6.4 | 1.6 | 9.2 | 154.1 | 110 | 53 | 53 | 19 | 28 | 158 | 7 | 0 | 0 | 3 | 15 | 1 | 4 | 3.12 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 88 | 20 | 20 | 4 | 6 | 6.34 | .352 | 1.58 | 10.9 | 3.4 | 9.0 | 109.1 | 132 | 78 | 77 | 28 | 41 | 109 | 0 | 0 | 0 | 0 | 4 | 5 | 1 | 5.61 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 78 | 20 | 20 | 5 | 7 | 6.45 | .349 | 1.56 | 10.4 | 3.6 | 9.1 | 113.0 | 131 | 81 | 81 | 17 | 45 | 114 | 2 | 0 | 0 | 1 | 7 | 6 | 5 | 4.29 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 68 | 20 | 20 | 11 | 7 | 4.68 | .307 | 1.30 | 9.0 | 2.8 | 6.2 | 117.1 | 117 | 62 | 61 | 14 | 36 | 80 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 4.19 |
| SP | Bush, D.Bush, David † # >> | 27 | 2006 | R | 40 | 21 | 19 | 14 | 4 | 3.46 | .284 | 1.17 | 8.5 | 2.1 | 6.4 | 132.2 | 124 | 58 | 51 | 20 | 31 | 94 | 3 | 0 | 0 | 1 | 13 | 3 | 2 | 4.32 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 86 | 47 | 0 | 6 | 2 | 2.70 | .256 | 0.97 | 6.8 | 2.0 | 6.3 | 60.0 | 45 | 19 | 18 | 10 | 13 | 42 | 0 | 1 | 1 | 0 | 0 | 4 | 5 | 4.62 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 40 | 0 | 3 | 2 | 5.19 | .314 | 1.31 | 9.9 | 2.0 | 7.9 | 50.1 | 55 | 31 | 29 | 15 | 11 | 44 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 5.98 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 35 | 0 | 2 | 1 | 1.87 | .301 | 1.22 | 7.3 | 3.8 | 10.0 | 43.1 | 35 | 10 | 9 | 1 | 18 | 48 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 2.53 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 60 | 31 | 0 | 0 | 1 | 3.82 | .313 | 1.30 | 7.6 | 4.1 | 8.7 | 33.0 | 28 | 14 | 14 | 3 | 15 | 32 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.79 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 36 | 0 | 2 | 3 | 3.11 | .266 | 1.06 | 4.9 | 4.9 | 10.9 | 37.2 | 20 | 13 | 13 | 1 | 20 | 45 | 0 | 22 | 2 | 0 | 0 | 1 | 2 | 2.62 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 37 | 0 | 1 | 2 | 3.03 | .270 | 1.09 | 7.1 | 2.8 | 10.4 | 38.2 | 30 | 13 | 13 | 5 | 12 | 44 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.42 |