| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 21 | 21 | 9 | 7 | 2.91 | .278 | 1.14 | 7.8 | 2.5 | 10.2 | 145.1 | 125 | 50 | 47 | 12 | 40 | 164 | 1 | 0 | 0 | 1 | 16 | 3 | 4 | 2.70 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 21 | 21 | 10 | 6 | 3.57 | .282 | 1.16 | 8.6 | 1.9 | 5.3 | 141.0 | 134 | 59 | 56 | 13 | 30 | 83 | 5 | 0 | 0 | 1 | 13 | 2 | 0 | 3.70 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 72 | 20 | 20 | 9 | 7 | 5.58 | .330 | 1.46 | 8.9 | 4.3 | 6.1 | 109.2 | 108 | 72 | 68 | 17 | 52 | 74 | 1 | 0 | 0 | 0 | 9 | 2 | 2 | 5.16 |
| SP | Lackey, J.Lackey, John >> | 29 | 2007 | R | 11 | 20 | 18 | 5 | 9 | 7.37 | .350 | 1.57 | 11.1 | 3.1 | 5.5 | 90.1 | 111 | 78 | 74 | 19 | 31 | 55 | 0 | 0 | 1 | 0 | 5 | 4 | 2 | 5.69 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 55 | 0 | 4 | 2 | 3.61 | .272 | 1.09 | 7.3 | 2.6 | 9.9 | 62.1 | 50 | 25 | 25 | 8 | 18 | 68 | 0 | 29 | 2 | 0 | 0 | 2 | 4 | 3.45 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 84 | 61 | 0 | 2 | 4 | 4.42 | .344 | 1.54 | 9.0 | 4.9 | 9.3 | 59.0 | 59 | 36 | 29 | 10 | 32 | 61 | 0 | 0 | 5 | 0 | 0 | 2 | 3 | 4.86 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 81 | 56 | 0 | 3 | 1 | 2.97 | .295 | 1.26 | 7.0 | 4.4 | 8.3 | 63.2 | 49 | 22 | 21 | 8 | 31 | 58 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.29 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 43 | 50 | 0 | 3 | 1 | 3.64 | .303 | 1.29 | 8.6 | 3.1 | 7.0 | 64.1 | 61 | 29 | 26 | 9 | 22 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.34 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 43 | 0 | 2 | 3 | 4.38 | .260 | 1.01 | 6.8 | 2.4 | 10.1 | 49.1 | 37 | 24 | 24 | 14 | 13 | 55 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.39 |