| SP | Wacha, M.Wacha, Michael >> | 32 | 2022 | R | 76 | 33 | 33 | 10 | 8 | 4.70 | .317 | 1.37 | 9.5 | 2.9 | 9.2 | 162.2 | 171 | 85 | 85 | 31 | 52 | 166 | 0 | 0 | 0 | 0 | 11 | 3 | 6 | 4.46 |
| SP | Pivetta, N.Pivetta, Nick >> | 31 | 2022 | R | 57 | 33 | 33 | 11 | 11 | 4.56 | .311 | 1.30 | 8.2 | 3.5 | 10.5 | 181.2 | 165 | 97 | 92 | 27 | 71 | 212 | 0 | 0 | 0 | 0 | 15 | 10 | 7 | 3.94 |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 34 | 2022 | R | 49 | 32 | 32 | 12 | 10 | 4.15 | .295 | 1.23 | 8.9 | 2.2 | 8.3 | 180.0 | 178 | 88 | 83 | 26 | 43 | 166 | 0 | 0 | 0 | 0 | 16 | 5 | 2 | 3.83 |
| SP | Crawford, K.Crawford, Kutter >> | 28 | 2022 | R | 35 | 31 | 31 | 4 | 6 | 4.62 | .312 | 1.34 | 9.1 | 3.0 | 8.7 | 122.2 | 124 | 64 | 63 | 27 | 40 | 118 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 5.00 |
| CL | Schreiber, J.Schreiber, John >> | 30 | 2022 | R | 99 | 71 | 0 | 2 | 4 | 4.35 | .333 | 1.45 | 8.9 | 4.2 | 12.0 | 62.0 | 61 | 31 | 30 | 13 | 29 | 83 | 0 | 37 | 6 | 0 | 0 | 3 | 3 | 4.60 |
| RP | Whitlock, G.Whitlock, Garrett >> | 28 | 2022 | R | 94 | 102 | 0 | 10 | 2 | 2.53 | .268 | 1.07 | 7.4 | 2.3 | 11.3 | 139.0 | 114 | 44 | 39 | 18 | 35 | 175 | 0 | 2 | 1 | 0 | 0 | 4 | 2 | 3.01 |
| RP | Houck, T.Houck, Tanner >> | 28 | 2022 | R | 91 | 87 | 0 | 7 | 6 | 4.47 | .305 | 1.27 | 8.2 | 3.3 | 10.0 | 104.2 | 95 | 59 | 52 | 20 | 38 | 116 | 0 | 3 | 9 | 0 | 0 | 5 | 5 | 4.51 |
| RP | Strahm, M.Strahm, Matt >> | 32 | 2022 | L | 61 | 111 | 0 | 1 | 7 | 6.42 | .355 | 1.63 | 10.6 | 4.1 | 10.9 | 74.1 | 87 | 56 | 53 | 16 | 34 | 90 | 0 | 2 | 7 | 0 | 0 | 2 | 8 | 4.84 |
| RP | Banuelos, M.Banuelos, Manny # >> | 33 | 2022 | L | 59 | 91 | 0 | 2 | 4 | 4.50 | .300 | 1.27 | 7.1 | 4.4 | 12.3 | 66.0 | 52 | 34 | 33 | 10 | 32 | 90 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Jansen, K.Jansen, Kenley >> | 35 | 2023 | R | 50 | 69 | 0 | 7 | 4 | 5.00 | .312 | 1.33 | 9.3 | 2.8 | 10.9 | 72.0 | 74 | 40 | 40 | 13 | 22 | 87 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 3.93 |
| SP | Bello, B.Bello, Brayan # >> | 25 | 2022 | R | 17 | 45 | 0 | 12 | 2 | 5.12 | .331 | 1.42 | 9.3 | 3.6 | 8.9 | 126.2 | 130 | 82 | 72 | 18 | 50 | 124 | 0 | 3 | 0 | 0 | 0 | 8 | 3 | 4.27 |