| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 31 | 31 | 8 | 17 | 4.08 | .300 | 1.26 | 9.0 | 2.4 | 5.6 | 225.0 | 225 | 105 | 102 | 42 | 59 | 140 | 7 | 0 | 0 | 1 | 19 | 5 | 3 | 5.04 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 33 | 33 | 9 | 21 | 4.90 | .323 | 1.41 | 10.1 | 2.7 | 5.0 | 249.2 | 279 | 151 | 136 | 44 | 74 | 137 | 11 | 0 | 0 | 1 | 12 | 4 | 3 | 5.14 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 75 | 33 | 33 | 13 | 19 | 5.10 | .314 | 1.35 | 8.7 | 3.5 | 4.8 | 242.0 | 233 | 148 | 137 | 44 | 94 | 130 | 15 | 0 | 0 | 0 | 12 | 6 | 3 | 5.53 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 63 | 32 | 31 | 15 | 12 | 4.95 | .311 | 1.35 | 8.0 | 4.2 | 4.6 | 194.2 | 173 | 115 | 107 | 33 | 90 | 100 | 3 | 0 | 0 | 2 | 13 | 1 | 1 | 5.59 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 82 | 0 | 6 | 3 | 3.40 | .251 | 1.00 | 6.2 | 2.8 | 9.8 | 111.1 | 77 | 42 | 42 | 12 | 34 | 121 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 3.17 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 84 | 63 | 0 | 3 | 3 | 5.16 | .342 | 1.50 | 7.9 | 5.6 | 9.5 | 68.0 | 60 | 41 | 39 | 6 | 42 | 72 | 0 | 10 | 2 | 0 | 0 | 4 | 2 | 4.06 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 82 | 38 | 0 | 0 | 2 | 3.72 | .317 | 1.37 | 8.4 | 3.9 | 9.4 | 46.0 | 43 | 19 | 19 | 4 | 20 | 48 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 72 | 31 | 0 | 1 | 2 | 3.53 | .331 | 1.49 | 8.0 | 5.7 | 7.2 | 35.2 | 31 | 20 | 14 | 3 | 22 | 28 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 4.40 |