| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 14 | 14 | 6 | 7 | 3.22 | .267 | 1.04 | 6.9 | 2.4 | 5.6 | 103.1 | 79 | 39 | 37 | 6 | 28 | 64 | 7 | 0 | 0 | 2 | 10 | 6 | 0 | 3.50 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 13 | 13 | 4 | 3 | 4.94 | .315 | 1.37 | 8.4 | 4.0 | 7.9 | 85.2 | 79 | 52 | 47 | 11 | 38 | 75 | 3 | 0 | 0 | 0 | 6 | 1 | 3 | 4.29 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 13 | 13 | 8 | 4 | 3.29 | .246 | 0.96 | 7.0 | 1.7 | 4.9 | 98.1 | 76 | 40 | 36 | 14 | 18 | 53 | 4 | 0 | 0 | 4 | 6 | 2 | 1 | 4.39 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 12 | 12 | 7 | 3 | 2.84 | .235 | 0.92 | 6.9 | 1.4 | 6.0 | 92.0 | 71 | 29 | 29 | 8 | 14 | 61 | 8 | 0 | 0 | 4 | 8 | 0 | 1 | 3.26 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 24 | 0 | 3 | 0 | 1.26 | .271 | 1.12 | 6.1 | 4.2 | 8.4 | 28.2 | 19 | 4 | 4 | 0 | 13 | 26 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 2.54 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 17 | 0 | 1 | 0 | 2.95 | .247 | 0.98 | 5.5 | 3.5 | 6.0 | 18.1 | 11 | 6 | 6 | 2 | 7 | 12 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 7 | 0 | 2 | 0 | 0.93 | .171 | 0.62 | 4.0 | 2.0 | 11.0 | 9.2 | 4 | 1 | 1 | 0 | 2 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.22 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 5 | 0 | 2 | 0 | 6.75 | .368 | 1.75 | 9.0 | 6.8 | 2.3 | 4.0 | 4 | 3 | 3 | 1 | 3 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 8.00 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 3 | 0 | 1 | 0 | 1.69 | .158 | 0.56 | 5.4 | 0.0 | 9.0 | 5.1 | 3 | 1 | 1 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.60 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 9 | 0 | 1 | 0 | 2.31 | .239 | 0.94 | 5.7 | 3.3 | 8.2 | 11.2 | 7 | 3 | 3 | 0 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.27 |