| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 11 | 11 | 3 | 3 | 3.83 | .310 | 1.34 | 8.9 | 3.2 | 7.0 | 80.0 | 79 | 35 | 34 | 5 | 28 | 62 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 3.35 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 10 | 10 | 6 | 2 | 3.25 | .280 | 1.15 | 8.0 | 2.4 | 5.8 | 72.0 | 64 | 27 | 26 | 3 | 19 | 46 | 1 | 0 | 0 | 1 | 7 | 1 | 1 | 3.10 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 16 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 4.2 | 1.2 | 10.2 | 15.0 | 7 | 0 | 0 | 0 | 2 | 17 | 0 | 16 | 0 | 0 | 0 | 0 | 1 | 1.13 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 21 | 0 | 1 | 2 | 1.74 | .235 | 0.92 | 6.3 | 2.3 | 6.3 | 20.2 | 14 | 4 | 4 | 0 | 5 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.35 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 15 | 0 | 2 | 0 | 2.93 | .324 | 1.43 | 8.4 | 4.8 | 9.0 | 15.1 | 14 | 8 | 5 | 3 | 8 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.20 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 6 | 0 | 1 | 0 | 2.70 | .259 | 1.05 | 9.0 | 1.5 | 6.0 | 6.2 | 6 | 2 | 2 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.17 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 4 | 0 | 1 | 0 | 22.50 | .625 | 5.00 | 18.0 | 27.0 | 9.0 | 2.0 | 4 | 5 | 5 | 2 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 23.00 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 6 | 0 | 0 | 0 | 6.35 | .346 | 1.59 | 12.6 | 3.6 | 7.2 | 5.2 | 7 | 4 | 4 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.60 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 4 | 0 | 0 | 1 | 5.79 | .398 | 1.98 | 12.0 | 6.5 | 3.0 | 18.2 | 24 | 14 | 12 | 0 | 13 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |