| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 29 | 29 | 10 | 7 | 4.14 | .301 | 1.29 | 7.9 | 3.7 | 7.5 | 152.0 | 134 | 72 | 70 | 19 | 62 | 126 | 0 | 0 | 0 | 0 | 12 | 0 | 2 | 4.19 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 28 | 28 | 12 | 3 | 3.13 | .288 | 1.20 | 8.2 | 2.6 | 4.9 | 167.0 | 152 | 60 | 58 | 6 | 48 | 91 | 0 | 0 | 0 | 0 | 19 | 3 | 3 | 3.29 |
| SP | Scott, M.Scott, Mike # >> | 31 | 1986 | R | 87 | 28 | 28 | 13 | 7 | 4.67 | .310 | 1.33 | 9.2 | 2.7 | 7.6 | 158.0 | 162 | 86 | 82 | 23 | 48 | 133 | 0 | 0 | 0 | 0 | 14 | 3 | 3 | 4.18 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 29 | 27 | 9 | 8 | 4.43 | .325 | 1.42 | 9.7 | 3.1 | 5.9 | 158.1 | 171 | 84 | 78 | 17 | 54 | 104 | 1 | 2 | 0 | 1 | 12 | 4 | 6 | 4.18 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 75 | 0 | 10 | 4 | 3.93 | .295 | 1.22 | 7.2 | 3.9 | 9.0 | 105.1 | 84 | 46 | 46 | 11 | 45 | 105 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.73 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 67 | 0 | 6 | 5 | 3.25 | .257 | 1.02 | 6.3 | 2.9 | 10.5 | 108.0 | 75 | 41 | 39 | 11 | 35 | 126 | 0 | 15 | 6 | 0 | 0 | 2 | 0 | 3.02 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 63 | 0 | 4 | 4 | 1.65 | .225 | 0.87 | 4.7 | 3.2 | 8.9 | 71.0 | 37 | 13 | 13 | 4 | 25 | 70 | 0 | 18 | 1 | 0 | 0 | 0 | 2 | 2.82 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 32 | 0 | 5 | 2 | 2.34 | .249 | 0.97 | 6.6 | 2.1 | 7.7 | 42.1 | 31 | 11 | 11 | 3 | 10 | 36 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.00 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 22 | 0 | 4 | 1 | 3.47 | .314 | 1.29 | 5.5 | 6.3 | 11.3 | 23.1 | 14 | 10 | 9 | 1 | 16 | 29 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.39 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 23 | 2 | 6 | 1 | 3.42 | .303 | 1.29 | 8.9 | 2.7 | 6.1 | 102.2 | 101 | 39 | 39 | 8 | 31 | 69 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 3.64 |