| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 34 | 34 | 14 | 12 | 3.65 | .277 | 1.13 | 7.6 | 2.5 | 8.3 | 266.2 | 225 | 113 | 108 | 27 | 75 | 245 | 7 | 0 | 0 | 2 | 20 | 6 | 1 | 3.39 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 17 | 4.71 | .291 | 1.20 | 8.2 | 2.6 | 7.7 | 235.0 | 213 | 125 | 123 | 40 | 69 | 200 | 8 | 0 | 0 | 0 | 18 | 7 | 5 | 4.48 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 31 | 31 | 10 | 13 | 5.14 | .312 | 1.34 | 9.8 | 2.2 | 4.7 | 218.2 | 238 | 128 | 125 | 29 | 54 | 115 | 5 | 0 | 0 | 1 | 11 | 5 | 3 | 4.49 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 30 | 30 | 7 | 11 | 5.09 | .325 | 1.42 | 8.1 | 4.7 | 4.2 | 203.1 | 182 | 125 | 115 | 17 | 107 | 95 | 2 | 0 | 0 | 0 | 14 | 5 | 3 | 4.81 |
| RP | Sutter, B.Sutter, Bruce † >> | 24 | 1977 | R | 68 | 72 | 0 | 8 | 2 | 2.67 | .301 | 1.28 | 7.9 | 3.6 | 8.4 | 84.1 | 74 | 30 | 25 | 7 | 34 | 78 | 0 | 8 | 3 | 0 | 0 | 1 | 2 | 3.48 |
| RP | Gordon, T.Gordon, Tom # >> | 37 | 2004 | R | 63 | 57 | 0 | 6 | 5 | 6.24 | .332 | 1.46 | 9.7 | 3.5 | 7.2 | 66.1 | 71 | 46 | 46 | 11 | 26 | 53 | 0 | 10 | 5 | 0 | 0 | 2 | 1 | 4.83 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 46 | 0 | 0 | 6 | 3.33 | .319 | 1.40 | 8.5 | 4.2 | 7.4 | 51.1 | 48 | 20 | 19 | 5 | 24 | 42 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 4.04 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 1 | 1 | 1 | 0 | 0.00 | .250 | 1.00 | 5.1 | 3.9 | 9.0 | 7.0 | 4 | 0 | 0 | 0 | 3 | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2.29 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 59 | 4 | 0 | 0 | 1 | 5.40 | .306 | 1.32 | 7.9 | 4.5 | 1.1 | 8.1 | 7 | 5 | 5 | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.50 |